Results 31 to 40 of about 9,029,134 (304)

Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function

Nature Communications, 2020
3D bioprinting of skeletal muscle using primary human muscle progenitor cells results in correct muscle architecture, but functional restoration in rodent models is limited. Here the authors include human neural stem cells into bioprinted skeletal muscle
Ji Hyun Kim, Ickhee Kim, Young-Joon Seol, In Kap Ko, James J. Yoo, Anthony Atala, Sang Jin Lee   +6 more
doaj   +1 more source

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

eLife, 2021
Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use fibrodysplasia ossificans progressiva (FOP), a disease of progressive HO caused by ACVR1R206H (Activin ...
Emilie Barruet, Steven M Garcia, Jake Wu, Blanca M Morales, Stanley Tamaki, Tania Moody, Jason H Pomerantz, Edward C Hsiao   +7 more
doaj   +1 more source

Weightlifting outperforms voluntary wheel running for improving adiposity and insulin sensitivity in obese mice

Journal of Sport and Health Science
Background: Exercise is an effective intervention for obesity and type 2 diabetes, with significant physiological benefits over pharmacological interventions.
Robert J. Shute, Ryan N. Montalvo, Wenqing Shen, Yuntian Guan, Qing Yu, Mei Zhang, Zhen Yan   +6 more
doaj   +1 more source

Evidence that muscle cells do not express the histidine-rich glycoprotein associated with AMP deaminase but can internalise the plasma protein

European Journal of Histochemistry, 2011
Histidine-rich glycoprotein (HRG) is synthesized by liver and is present at relatively high concentration in the plasma of vertebrates. We have previously described the association of a HRG-like molecule to purified rabbit skeletal muscle AMP deaminase ...
A.R.M. Sabbatini, L. Mattii, B. Battolla, E. Polizzi, D. Martini, M. Ranieri-Raggi, A.J.G. Moir, A. Raggi   +7 more
doaj   +1 more source

Skeletal muscle mTORC1 regulates whole-body metabolism [PDF]

, 2015
Skeletal muscle, which represents over 40% of the total body mass, is a dynamic tissue with a key role in the maintenance of metabolic homeostasis. Several lines of evidence indicate that alterations of the normal muscle function, as for example in ...
Ormazabal, Maitea Guridi
core   +1 more source

The ERG1A K⁺ Channel Is More Abundant in Rectus abdominis Muscle from Cancer Patients Than that from Healthy Humans

Diagnostics, 2021
Background: The potassium channel encoded by the ether-a-gogo-related gene 1A (erg1a) has been detected in the atrophying skeletal muscle of mice experiencing either muscle disuse or cancer cachexia and further evidenced to contribute to muscle ...
Sandra Zampieri, Marco Sandri, Joseph L. Cheatwood, Rajesh P. Balaraman, Luke B. Anderson, Brittan A. Cobb, Chase D. Latour, Gregory H. Hockerman, Helmut Kern, Roberta Sartori, Barbara Ravara, Stefano Merigliano, Gianfranco Da Dalt, Judith K. Davie, Punit Kohli, Amber L. Pond   +15 more
doaj   +1 more source

Biochemical diversity of human skeletal muscle [PDF]

The FASEB Journal, 2012
INTRODUCTION The molecular components largely responsible for muscle attributes such as passive tension development (titin and collagen), active tension development (myosin heavy chain [MHC]), and mechanosensitive signaling (titin) are well studied in animals but less is known about their roles in humans.
Tirrell, Timothy F., Cook, Mark, Carr, John A., Choi, Anthony J., Lin, Evie, Esparza, Mary C., Ward, Samuel R., Lieber, Richard L.   +7 more
openaire   +1 more source

Pathological Mechanism of a Constitutively Active Form of Stromal Interaction Molecule 1 in Skeletal Muscle

Biomolecules, 2021
Stromal interaction molecule 1 (STIM1) is the main protein that, along with Orai1, mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. Abnormal SOCE due to mutations in STIM1 is one of the causes of human skeletal muscle diseases.
Ji Hee Park, Seung Yeon Jeong, Jun Hee Choi, Eun Hui Lee   +3 more
doaj   +1 more source

Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology [PDF]

, 2014
Skeletal muscle is an organ involved in whole body movement and energy metabolism with the ability to dynamically adapt to different states of (dis-)use.
Handschin, Christoph, Eisele, Petra S., Eisele PS, Handschin C   +3 more
core   +1 more source

Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway [PDF]

, 2012
Skeletal muscle atrophy induced by aging (sarcopenia), inactivity, and prolonged fasting states (starvation) is predominantly restricted to glycolytic type II muscle fibers and typical spares oxidative type I fibers.
Bastie, Claire C., Claire C. Bastie, Jeffrey E. Pessin, Ana Maria Cuervo, Yichen Wang, Eijiro Yamada, Hiroshi Koga, Yamada, Eijiro, Eijiro Yamada, Koga, Hiroshi, Wang, Yichen, Cuervo, Ana Maria, Pessin, Jeffrey E.   +12 more
core   +1 more source