Results 11 to 20 of about 9,029,134 (304)

An epigenetic clock for human skeletal muscle [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2019
Abstract Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the original pan-tissue epigenetic clock did not include skeletal muscle ...
Voisin, S, Harvey, NR, Haupt, LM, Griffiths, LR, Ashton, KJ, Coffey, VG, Doering, TM, Thompson, JM, Benedict, C, Cedernaes, J, Lindholm, ME, Craig, JM, Rowlands, DS, Sharples, AP, Horvath, S, Eynon, N   +15 more
openaire   +7 more sources

A ribonuclease from human skeletal muscle [PDF]

Biochemical Journal, 1970
1. A ribonuclease has been prepared from human muscle by ammonium sulphate fractionation, heat treatment and ion-exchange chromatography. 2. The enzyme degrades polycytidylic acid and polyuridylic acid to the nucleoside 3′-phosphates, with nucleoside 2′:3′-cyclic phosphates as intermediates. Polyadenylic acid and polyguanylic acid are not attacked.
D F, Goldspink, R J, Pennington
openaire   +2 more sources

A non-linear approach to modelling of electrically stimulated skeletal muscle [PDF]

, 2001
This paper is concerned with the development and analysis of a nonlinear approach to modeling of the contraction of electrically stimulated skeletal muscle.
Gollee, H., Murray-Smith, D.J., Jarvis, J.C.   +2 more
core   +6 more sources

Leptin receptors in human skeletal muscle [PDF]

The FASEB Journal, 2007
The aim of this study was to determine if leptin receptors (OB‐R) are expressed at the protein level in human skeletal muscle. Muscle biopsies were obtained from the musculus vastus lateralis in fourteen, healthy men (age = 33.1 ± 2 yr, height = 175.9 ± 1.7 cm, body mass = 81.2 ± 3.8 kg, body fat = 22.5 ± 1.9%).
Guerra, Borja, Santana, Alfredo, Fuentes Nieto, Teresa, Delgado Guerra, Safira, Cabrera Socorro, Alfredo, Dorado, Cecilia, Calbet, Jose A. L.   +6 more
openaire   +5 more sources

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering

Cell Reports, 2018
Summary: Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including ...
Sara Martina Maffioletti, Shilpita Sarcar, Alexander B.H. Henderson, Ingra Mannhardt, Luca Pinton, Louise Anne Moyle, Heather Steele-Stallard, Ornella Cappellari, Kim E. Wells, Giulia Ferrari, Jamie S. Mitchell, Giulia E. Tyzack, Vassilios N. Kotiadis, Moustafa Khedr, Martina Ragazzi, Weixin Wang, Michael R. Duchen, Rickie Patani, Peter S. Zammit, Dominic J. Wells, Thomas Eschenhagen, Francesco Saverio Tedesco   +21 more
doaj   +1 more source

Changes in intracellular ion activities induced by adrenaline in human and rat skeletal muscle [PDF]

, 1988
To study the stimulating effect of adrenaline (ADR) on active Na+/K+ transport we used double-barrelled ion-sensitive micro-electrodes to measure the activities of extracellular K+ (aKe) and intracellular Na+ (aNai) in isolated preparations of rat soleus
Ballanyi, Klaus, Grafe, Peter
core   +1 more source

Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation

Molecular Metabolism, 2020
Objective: Estrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle.
Melissa R. Iñigo, Adam J. Amorese, Michael D. Tarpey, Nicholas P. Balestrieri, Keith G. Jones, Daniel J. Patteson, Kathryn C. Jackson, Maria.J. Torres, Chien-Te Lin, Cody D. Smith, Timothy D. Heden, Shawna L. McMillin, Luke A. Weyrauch, Erin C. Stanley, Cameron A. Schmidt, Brita B. Kilburg-Basnyat, Sky W. Reece, Christine E. Psaltis, Leslie A. Leinwand, Katsu Funai, Joseph M. McClung, Kymberly M. Gowdy, Carol A. Witczak, Dawn A. Lowe, P. Darrell Neufer, Espen E. Spangenburg   +25 more
doaj   +1 more source

New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases [PDF]

, 2013
Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases ...
Handschin, Christoph, Pérez-Schindler, Joaquín   +1 more
core   +1 more source

Immunohistochemical Identification of Human Skeletal Muscle Macrophages

Bio-Protocol, 2018
Macrophages have well-characterized roles in skeletal muscle repair and regeneration. Relatively little is known regarding the role of resident macrophages in skeletal muscle homeostasis, extracellular matrix remodeling, growth, metabolism and adaptation
Kate Kosmac, Bailey Peck, R. Walton, Jyothi Mula, Philip Kern, Marcas Bamman, Richard Dennis, Cale Jacobs, Christian Lattermann, Darren Johnson, Charlotte Peterson   +10 more
doaj   +1 more source

Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres [PDF]

, 1989
The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as K+ channel openers, on the electrical activity of human skeletal muscle.
Lehmann-Horn, Frank, Grafe, Peter, Spuler, A.   +2 more
core   +1 more source