Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle
Bioactive Materials, 2023 Skeletal muscle disorders have posed great threats to health. Selective delivery of drugs and oligonucleotides to skeletal muscle is challenging. Aptamers can improve targeting efficacy.
Shuming Sun +11 more
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A Biomimetic 3D Human Skeletal Muscle Microtissue for Modeling Biological and Functional Hallmarks of Aging [PDF]
Small ScienceSkeletal muscle is one of the largest organs in the human body, playing a central role in mobility, metabolism, and endocrine regulation. The aging global population underscores the need to understand skeletal muscle aging, which is bottlenecked by the ...
Sohae Yang +9 more
doaj +2 more sources
Human skeletal muscle mitochondrial pathways are impacted by a neuropathologic diagnosis of Alzheimer's disease [PDF]
Neurobiology of DiseaseAlzheimer's disease (AD) is associated with reduced lean mass and impaired skeletal muscle mitochondrial and motor function. Although primary mitochondrial defects in AD may underlie these findings, molecular alterations in AD have not been thoroughly ...
Chelsea N. Johnson +11 more
doaj +2 more sources
Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research [PDF]
Endocrinology and Metabolism, 2022 Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle and other metabolic organs in terms of systemic energy ...
Ji-Hoon Kim, Seung-Min Yu, Jang Won Son
doaj +1 more source
Human Nutrition & Metabolism, 2023 Objectives: This study aimed to verify the acute effect of Capsiate (CAP) on muscle endurance resistance training during CrossFit® and to compare the effects of two acute doses of CAP supplementation (12 vs.
Marcelo da Silva Mesquita Oliveira +8 more
doaj +1 more source
New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin
Frontiers in Physiology, 2022 Human postmortem skeletal muscles are a unique source of satellite cells for skeletal muscle regenerative studies. Presomite and somite satellite cells obtained by postmortem muscles have been established as populations of human skeletal muscle precursor
Tiziana Pietrangelo +19 more
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Anserine is expressed in human cardiac and skeletal muscles
Physiological Reports, 2023 We evaluated whether anserine, a methylated analog of the dipeptide carnosine, is present in the cardiac and skeletal muscles of humans and whether the CARNMT1 gene, which encodes the anserine synthesizing enzyme carnosine‐N‐methyltransferase, is ...
Lívia deSouza Gonçalves +9 more
doaj +1 more source
Defining the Skeletal Myogenic Lineage in Human Pluripotent Stem Cell-Derived Teratomas
Cells, 2022 Skeletal muscle stem cells are essential to muscle homeostasis and regeneration after injury, and have emerged as a promising cell source for treating skeletal disorders.
Matthew P. Pappas +3 more
doaj +1 more source
Lactate-induced lactylation in skeletal muscle is associated with insulin resistance in humans
Frontiers in Physiology, 2022 Elevated circulating lactate has been associated with obesity and insulin resistance. The aim of the current study was to determine if lactate-induced lysine lactylation (kla), a post-translational modification, was present in human skeletal muscle and ...
Dominic Maschari +7 more
doaj +1 more source
Recent Trends in Biofabrication Technologies for Studying Skeletal Muscle Tissue-Related Diseases
Frontiers in Bioengineering and Biotechnology, 2021 In native skeletal muscle, densely packed myofibers exist in close contact with surrounding motor neurons and blood vessels, which are embedded in the fibrous connective tissue.
Seungyeun Cho +4 more
doaj +1 more source