Results 21 to 30 of about 9,029,134 (304)

Regulation of skeletal muscle plasticity by the transcriptional coregulators PGC-1α and NCoR1 [PDF]

, 2013
Skeletal muscle plasticity is regulated by a wide range of factors, among which environmental stimuli such as exercise play a central role. Importantly, changes in skeletal muscle phenotype exert a direct impact on health and risk to premature death.
Pérez-Schindler, Joaquín
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Bioengineered Viral Platform for Intramuscular Passive Vaccine Delivery to Human Skeletal Muscle

Molecular Therapy: Methods & Clinical Development, 2018
Skeletal muscle is ideal for passive vaccine administration as it is easily accessible by intramuscular injection. Recombinant adeno-associated virus (rAAV) vectors are in consideration for passive vaccination clinical trials for HIV and influenza ...
Nicole K. Paulk, Katja Pekrun, Gregory W. Charville, Katie Maguire-Nguyen, Michael N. Wosczyna, Jianpeng Xu, Yue Zhang, Leszek Lisowski, Bryan Yoo, Jose G. Vilches-Moure, Gordon K. Lee, Joseph B. Shrager, Thomas A. Rando, Mark A. Kay   +13 more
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Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants

Journal of Diabetes Research, 2021
Context. Skeletal muscle insulin resistance is one of the primary contributors of type 2 diabetes (T2D). Metformin is the first-line drug for the treatment of T2D.
Aktham Mestareehi, Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty, Abdullah Mallisho, Kyle Jon Burghardt, Anjaneyulu Kowluru, Zhengping Yi   +7 more
doaj   +1 more source

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Handschin, Christoph, Christoph Handschin, Kupr, Barbara, Barbara eKupr, Christoph eHandschin, Barbara Kupr, Handschin C, Kupr B   +7 more
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Skeletal Muscle Is an Endocrine Organ

Journal of Pharmacological Sciences, 2014
.: Skeletal muscle plays a key role in postural retention as well as locomotion for maintaining the physical activities of human life. Skeletal muscle has a second role as an elaborate energy production and consumption system that influences the whole ...
Kenji Iizuka, Takuji Machida, Masahiko Hirafuji   +2 more
doaj   +1 more source

The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency [PDF]

, 2010
Skeletal muscle contraction increases energy expenditure and improves metabolic flexibility, but is also a key regulator of metabolic gene expression.
Carson, Brian
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Noninvasive Estimation of Myosin Heavy Chain Composition in Human Skeletal Muscle [PDF]

, 2011
Purpose: Information on muscle fiber type composition is of great importance in muscle physiology and athletic performance. Because there are only a few techniques available that noninvasively and accurately provide an estimate of muscle fiber type ...
Rittweger, Jörn, JÖRN RITTWEGER, IGOR B. MEKJAVIĆ, Pisot, Rado, BOŠTJAN ŠIMUNIČ, Degens, Hans, Narici, M., Mekjavic, Igor, RADO PIŠOT, Pišot, R., MARCO NARICI, Degens, H., Simunic, Bostjan, Simunič, B., HANS DEGENS, Narici, Marco, Mekjavić, I. B., Rittweger, J.   +17 more
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Effects of inactivity on human muscle glutathione synthesis by a double-tracer and single-biopsy approach [PDF]

, 2010
Oxidative stress is often associated to inactivity-mediated skeletal muscle atrophy. Glutathione is one of the major antioxidant systems stimulated, both at muscular and systemic level, by activation of oxidative processes.
DALLA LIBERA L, Francesco Agostini, Biolo, Gianni, JURDANA M, Mihaela Jurdana, Sara Mazzucco, BIOLO G., Agostini, Francesco, Jörn Rittweger, Mazzucco, Sara, Jurdana, Mihaela, Luciano Dalla Libera, Narici, Marco, Gianni Biolo, Dalla Libera, Luciano, NARICI M, MEKJAVIC IB, Rittweger, Jörn, AGOSTINI F, Igor B. Mekjavic, Pisot, Rado, PISOT R, Mekjavic, Igor, MAZZUCCO S, Gorza, Luisa, Rado Pišot, RITTWEGER J, Marco Narici, Luisa Gorza, Gorza L   +29 more
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Human and Rodent Skeletal Muscles Express Angiotensin II Type 1 Receptors

Cells, 2020
Abundant evidence reveals that activation of the renin-angiotensin system promotes skeletal muscle atrophy in several conditions including congestive heart failure, chronic kidney disease, and prolonged mechanical ventilation. However, controversy exists
Rafael Deminice, Hayden Hyatt, Toshinori Yoshihara, Mustafa Ozdemir, Branden Nguyen, Sanford Levine, Scott Powers   +6 more
doaj   +1 more source

Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? [PDF]

, 2010
<p><b>Background:</b> South Asians are more insulin resistant than Europeans, which cannot be fully explained by differences in adiposity. We investigated whether differences in oxidative capacity and capacity for fatty acid utilisation
Nita G Forouhi, Jason M R Gill, Hall, L.M.L., Hariharan, Narayanan, Salt, I.P., Hall, Lesley M L, Wilson, John, Niall G. MacFarlane, Niall G MacFarlane, Sattar, N., Milne, Gillian R, Gillian R Milne, MacFarlane, N.G., Gill, Jason M R, Gill Jason M. R., Lesley M. L. Hall, Moran Colin N., John Wilson, Sattar Naveed, Jason M. R. Gill, Colin N Moran, Gillian R. Milne, MacFarlane Niall G., Lesley M L Hall, Forouhi, N.G., MacFarlane, Niall G, Hariharan, N., Ian P Salt, Colin N. Moran, Hariharan Narayanan, Milne, G.R., Sattar, Naveed, Gill, J.M.R., Moran, C.N., Milne Gillian R., Nita G. Forouhi, Forouhi Nita G., Salt Ian P., Naveed Sattar, Narayanan Hariharan, Moran, Colin Neil, Hall Lesley M. L., Forouhi, Nita G, Salt, Ian P, Ian P. Salt, Wilson John   +45 more
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