Results 61 to 70 of about 976,647 (347)

Multimodal cell atlas of the ageing human skeletal muscle

Nature
Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people1.
Yiwei Lai, Ignacio Ramírez-Pardo, Joan Isern, J. An, Eusebio Perdiguero, Antonio L. Serrano, Jinxiu Li, Esther García-Domínguez, J. Segalés, Pengcheng Guo, V. Lukesova, Eva Andrés, Jing Zuo, Yue Yuan, Chuanyu Liu, José Viña, J. Doménech-Fernández, M. Gómez-Cabrera, Yancheng Song, Longqi Liu, Xun Xu, P. Muñoz-Cánoves, Miguel A. Esteban   +22 more
semanticscholar   +1 more source

3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration

Scientific Reports, 2018
A bioengineered skeletal muscle tissue as an alternative for autologous tissue flaps, which mimics the structural and functional characteristics of the native tissue, is needed for reconstructive surgery.
J. Kim, Young-Joon Seol, I. Ko, Hyun-Wook Kang, Young Koo Lee, J. Yoo, A. Atala, S. Lee   +7 more
semanticscholar   +1 more source

Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors

eLife, 2020
Generation of skeletal muscle cells with human pluripotent stem cells (hPSCs) opens new avenues for deciphering essential, but poorly understood aspects of transcriptional regulation in human myogenic specification.
In Young Choi, Hotae Lim, Hyeon Jin Cho, Yohan Oh, Bin-Kuan Chou, Hao Bai, Linzhao Cheng, Yong Jun Kim, SangHwan Hyun, Hyesoo Kim, Joo Heon Shin, Gabsang Lee   +11 more
doaj   +1 more source

The breaking and making of healthy adult human skeletal muscle in vivo

Skeletal Muscle, 2017
BackgroundWhile muscle regeneration has been extensively studied in animal and cell culture models, in vivo myogenesis in adult human skeletal muscle has not been investigated in detail.MethodsUsing forced lengthening contractions induced by electrical ...
A. Mackey, M. Kjaer
semanticscholar   +1 more source

Vitamin D and Human Skeletal Muscle [PDF]

Scandinavian Journal of Medicine & Science in Sports, 2009
Vitamin D deficiency is an increasingly described phenomenon worldwide, with well-known impacts on calcium metabolism and bone health. Vitamin D has also been associated with chronic health problems such as bowel and colonic cancer, arthritis, diabetes and cardiovascular disease.
openaire   +2 more sources

Biochemical diversity of human skeletal muscle [PDF]

The FASEB Journal, 2012
INTRODUCTION The molecular components largely responsible for muscle attributes such as passive tension development (titin and collagen), active tension development (myosin heavy chain [MHC]), and mechanosensitive signaling (titin) are well studied in animals but less is known about their roles in humans.
Tirrell, Timothy F., Cook, Mark, Carr, John A., Choi, Anthony J., Lin, Evie, Esparza, Mary C., Ward, Samuel R., Lieber, Richard L.   +7 more
openaire   +1 more source

Intramyocellular Lipid Content in Human Skeletal Muscle [PDF]

Obesity, 2006
AbstractFat can be stored not only in adipose tissue but also in other tissues such as skeletal muscle. Fat droplets accumulated in skeletal muscle [intramyocellular lipids (IMCLs)] can be quantified by different methods, all with advantages and drawbacks.
Schrauwen-Hinderling, V.B., Hesselink, M.K., Schrauwen, P., Kooi, M.E.   +3 more
openaire   +2 more sources

Engineering Skeletal Muscle Grafts with PAX7::GFP-Sorted Human Pluripotent Stem Cell-Derived Myogenic Progenitors on Fibrin Microfiber Bundles for Tissue Regeneration

Bioengineering, 2022
Tissue engineering strategies that combine human pluripotent stem cell-derived myogenic progenitors (hPDMs) with advanced biomaterials provide promising tools for engineering 3D skeletal muscle grafts to model tissue development in vitro and promote ...
Sarah M. Somers, Jordana Gilbert-Honick, In Young Choi, Emily K. W. Lo, HoTae Lim, Shaquielle Dias, Kathryn R. Wagner, Hai-Quan Mao, Patrick Cahan, Gabsang Lee, Warren L. Grayson   +10 more
doaj   +1 more source

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

eLife, 2018
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes ...
L. Perrin, Ursula Loizides-Mangold, Stéphanie Chanon, C. Gobet, N. Hulo, Laura Isenegger, B. Weger, E. Migliavacca, A. Charpagne, J. Betts, J. Walhin, Iain Templeman, K. Stokes, D. Thompson, K. Tsintzas, Maud Robert, C. Howald, H. Riezman, J. Feige, L. Karagounis, J. Johnston, E. Dermitzakis, F. Gachon, E. Lefai, C. Dibner   +24 more
semanticscholar   +1 more source

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

Nature Communications, 2018
Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident stem cells.
Irene Franco, A. Johansson, K. Olsson, P. Vrtačnik, P. Lundin, Hafdís T. Helgadóttir, M. Larsson, Gwladys Revêchon, C. Bosia, A. Pagnani, P. Provero, T. Gustafsson, H. Fischer, M. Eriksson   +13 more
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