Results 81 to 90 of about 976,647 (347)

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Shift workers are affected by circadian misalignment and have an increased risk to develop metabolic diseases such as type 2 diabetes.
Jakob Wefers, Dirk van Moorsel, Jan Hansen, N. J. Connell, B. Havekes, J. Hoeks, W. D. van Marken Lichtenbelt, H. Duez, E. Phielix, A. Kalsbeek, M. Boekschoten, G. Hooiveld, M. Hesselink, S. Kersten, B. Staels, F. Scheer, P. Schrauwen   +16 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes

BMC Musculoskeletal Disorders, 2006
Background Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle.
Kang Peter B, Kho Alvin T, Kohane Isaac S, Kunkel Louis M   +3 more
doaj   +1 more source

Are cultured human myotubes far from home? [PDF]

, 2013
Satellite cells can be isolated from skeletal muscle biopsies, activated to proliferating myoblasts and differentiated into multinuclear myotubes in culture.
Aas, Vigdis, Bajpeyi, Sudip, Bakke, Siril Skaret, Feng, Yuan Zeng, Jensen, Jørgen, Kase, Eili Tranheim, Rustan, Arild, Thoresen, G. Hege   +7 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy [PDF]

, 2018
Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD gene.
Amoasii, L, Bassel-Duby, R, Caballero, D, Harron, R, Hildyard, J C W, Li, H, Massey, C A, Mireault, A, Olson, E N, Piercy, R J, Sanchez-Ortiz, E, Shelton, J M, Stathopoulou, T-R   +12 more
core   +2 more sources

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes

Frontiers in Cardiovascular Medicine, 2018
Glyoxalase-1 (GLO1) is a ubiquitously expressed cytosolic protein which plays a role in the natural maintenance of cellular health and is abundantly expressed in human skeletal muscle.
Jacob T. Mey, Jacob M. Haus
doaj   +1 more source

Human muscle-derived cell populations isolated by differential adhesion rates: Phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice [PDF]

, 2011
Muscle-derived stem cells (MDSCs) isolated from murine skeletal tissue by the preplate method have displayed the capability to commit to the myogenic lineage and regenerate more efficiently than myoblasts in skeletal and cardiac muscle in murine Duchenne
Bridget M. Deasy, Hwang J.H., Joseph M. Feduska, Pate D.W., Rebecca C. Schugar, Sinanan A.C., Steven M. Chirieleison, Williams J.T., Yuko Askew   +8 more
core   +2 more sources