Results 181 to 190 of about 17,530,541 (339)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Feasibility study of a newly developed solid gel pad containing tamarind seed gum for diagnostic ultrasonography in human subjects. [PDF]

Sci Rep
Uehara T, Monzen H, Ujifuku M, Matsuo Y, Watanabe Y.   +4 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Non-inclusive language in human subjects questionnaires: addressing racial, ethnic, heteronormative, and gender bias. [PDF]

BMC Public Health
Hernandez I, Nuñez V, Reynaga L, Stewart K, Hernandez-Castro I, Maldonado LE, Corona K, Aung M, Knapp EA, Fuselier G, Douglas C, Vega CV, Faro E, Frosch RM, Lewis J, Croen LA, Dunlop AL, Ganiban J, Keenan K, Bastain T, Environmental influences on Child Health Outcomes.   +20 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The role of individual characteristics of human subjects on the radiation burden of the bronchial airways from radon progeny. [PDF]

Radiat Environ Biophys
Füri P, Farkas Á, Hofmann W, Madas BG.
europepmc   +1 more source

Enhancing research and collaboration in forensic science: A primer on human subjects' research protection. [PDF]

Forensic Sci Int Synerg, 2023
Marciano MA, Hall A, Mozayani A, Cromp T, Maynard HP.   +4 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Mind the gap: bridging ethical considerations and regulatory oversight in implantable BCI human subjects research. [PDF]

Front Hum Neurosci
Wilkins RB, Coffin T, Pham M, Klein E, Marathe M.   +4 more
europepmc   +1 more source

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

Journal of Physiology, 2012
S. Larsen, Joachim Nielsen, C. N. Hansen, L. Nielsen, F. Wibrand, N. Stride, H. Schrøder, R. Boushel, J. Helge, F. Dela, Martin Hey‐Mogensen   +10 more
semanticscholar   +1 more source