Results 201 to 210 of about 17,530,541 (339)

Immune Dysregulation in Human Subjects With Heterozygous Germline Mutations in CTLA4

Pediatrics, 2015
T. Fleisher
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial. [PDF]

Metabolites
Chien AL, Liu H, Rachidi S, Feig JL, Wang R, Wade KL, Stephenson KK, Kecici AS, Fahey JW, Kang S.   +9 more
europepmc   +1 more source

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects.

Journal of Clinical Investigation, 2015
J. Traba, Miriam Kwarteng-Siaw, Tracy C Okoli, Jessica Li, Rebecca D Huffstutler, A. Bray, M. Waclawiw, Kim Han, M. Pelletier, A. Sauve, R. Siegel, M. Sack   +11 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Pharmacokinetic Analysis of the Bioavailability of AQUATURM^®, a Water-Soluble Curcumin Formulation, in Comparison to a Conventional Curcumin Tablet, in Human Subjects. [PDF]

Pharmaceuticals (Basel)
Jabur L, Pandey R, Mikhael M, Niedermayer G, Gyengesi E, Mahns D, Münch G.   +6 more
europepmc   +1 more source

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects.

Journal of Clinical Investigation, 2015
E. Boscolo, N. Limaye, Lan Huang, K. Kang, J. Soblet, M. Uebelhoer, A. Mendola, Marjut Natynki, Emmanuel Seront, S. Dupont, J. Hammer, C. Legrand, C. Brugnara, L. Eklund, M. Vikkula, J. Bischoff, L. Boon   +16 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Population Pharmacokinetic Modeling of Certepetide in Human Subjects With Metastatic Pancreatic Ductal Adenocarcinoma. [PDF]

Clin Pharmacol Drug Dev
Winning A, Sietsema WK, Buck KK, Linsmeier A, Wiczling P.   +4 more
europepmc   +1 more source

World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects Revised October 7, 2000

, 2001
Helsinki, Finland., June, Venice, H. Kong, September, Somerset West, Edinburgh, Scotland   +8 more
semanticscholar   +1 more source