Results 81 to 90 of about 17,530,541 (339)
A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. [PDF]
, 2015 Brown adipose tissue (BAT) has been proposed as a potential target tissue against obesity and its related metabolic complications. Although the molecular and functional characteristics of BAT have been intensively studied in rodents, only a few studies ...
Annamalai, P +6 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Informed consent: Issues and challenges
Journal of Advanced Pharmaceutical Technology & Research, 2013 Informed consent is an ethical and legal requirement for research involving human participants. It is the process where a participant is informed about all aspects of the trial, which are important for the participant to make a decision and after ...
Lokesh P Nijhawan +6 more
doaj +1 more source
A Controlled Increase in Dietary Phosphate Elevates BP in Healthy Human Subjects. [PDF]
, 2018 Background Despite epidemiologic evidence for increased cardiovascular morbidity and mortality associated with both high dietary and serum phosphate in humans with normal renal function, no controlled phosphate intervention studies of systemic ...
Bestmann, Lukas +4 more
core
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
, 2001 This paper explores, both wit This study reflects a recent shift towards the study of early stages of expert memory acquisition for chess positions. Over the course of fifteen sessions, two subjects who knew virtually nothing about the game of chess were
Gobet, F, Jackson, S
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Debating Ethical Research with Human Subjects
Acta Paedagogica Vilnensia, 2018 [full article in English] Drawing on our experience serving on an ethics review board in the United States, two scholars present three fictionalized examples to illustrate three issues in reviewing research proposals for the protection of human ...
Kathryn Roulston, Judith Preissle
doaj +1 more source
A Method for Remotely Sensing Vital Signs of Human Subjects Outdoors
Italian National Conference on Sensors, 2015 After chemical or nuclear leakage or explosions, finding survivors is a huge challenge. Although human bodies can be found by smart vehicles and drones equipped with cameras, it is difficult to verify if the person is alive or dead this way.
Chuantao Li +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source