Results 91 to 100 of about 2,454,904 (305)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Proposal of an Accessible Cabin Concept on Regional Aviation for Passengers with Disabilities
Journal of Aerospace Technology and ManagementDespite a global increase in the number of passengers with disabilities on regional aviation, most aircraft cabins are still not adequately equipped to provide sufficient comfort to this public, making the travel experience much less attractive.
Silvio Romero Oliveira Nascimento Filho +2 more
doaj
, 2017 Networks of coupled dynamical systems provide a powerful way to model systems with enormously complex dynamics, such as the human brain. Control of synchronization in such networked systems has far reaching applications in many domains, including ...
Abel, Markus +4 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Complex Systems Informatics and Modeling Quarterly, 2015 The 5th issue of the journal on Complex Systems Informatics and Modeling (CSIMQ) presents extended versions of five papers selected from the CAiSE Forum 2015.
Janis Grabis, Kurt Sandkuhl
doaj +1 more source
, 2019 Systems engineering processes coordinate the effort of different individuals to generate a product satisfying certain requirements. As the involved engineers are self-interested agents, the goals at different levels of the systems engineering hierarchy ...
Bilionis, Ilias +2 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Engineering Digital Systems for Humanity: Challenges and Opportunities
CoRRAs testified by new regulations like the European AI act, the worries about the societal impact of (autonomous) software technologies are becoming of public concern. Social and human values, besides the traditional software behaviour and quality, are increasingly recognized as important for sustainability and long-term well-being.
Martina De Sanctis +2 more
openaire +2 more sources
Human Factors Considerations in System Design [PDF]
Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined.
Mitchell, C. M. +2 more
core +1 more source
Human Factors Interface with Systems Engineering for NASA Human Spaceflights [PDF]
, 2009 This paper summarizes the past and present successes of the Habitability and Human Factors Branch (HHFB) at NASA Johnson Space Center s Space Life Sciences Directorate (SLSD) in including the Human-As-A-System (HAAS) model in many NASA programs and what ...
Wong, Douglas T.
core +1 more source