Results 101 to 110 of about 2,454,904 (305)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Finite Element Modeling of the Cortical Bone Region Using Clinical CT Images
Journal of Biomechanical Science and Engineering, 2006 Since the cortical bone has higher elastic modulus compared to the cancellous bone, its geometry is very important for stress analysis of bone structure.
Hiroki NAKATSUCHI +5 more
doaj +1 more source
Large space antennas: A systems analysis case history [PDF]
The value of systems analysis and engineering is aptly demonstrated by the work on Large Space Antennas (LSA) by the NASA Langley Spacecraft Analysis Branch.
Keafer, Lloyd S., Lovelace, U. M.
core +1 more source
Engineering Crowdsourced Stream Processing Systems [PDF]
, 2014 A crowdsourced stream processing system (CSP) is a system that incorporates crowdsourced tasks in the processing of a data stream. This can be seen as enabling crowdsourcing work to be applied on a sample of large-scale data at high speed, or ...
Carlos Castillo +4 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Engineering management of large scale systems [PDF]
The organization of high technology and engineering problem solving, has given rise to an emerging concept. Reasoning principles for integrating traditional engineering problem solving with system theory, management sciences, behavioral decision theory ...
Gill, Tepper L. +2 more
core +1 more source
Software for Wearable Devices: Challenges and Opportunities
, 2015 Wearable devices are a new form of mobile computer system that provides exclusive and user-personalized services. Wearable devices bring new issues and challenges to computer science and technology.
Chen, Xin +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Excitation System for Magnetic Resonance Elastography Using Micro MRI
Journal of Biomechanical Science and Engineering, 2012 Magnetic resonance elastography (MRE) is a nondestructive method for measuring the hardness and softness of living tissue by means of magnetic resonance imaging (MRI) coupled with mechanical excitation of the subject.
Shigeru TADANO +8 more
doaj +1 more source