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Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

open access: yesAdvanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong   +6 more
wiley   +1 more source

Multiscale 3D Whole Joint Cellular and Molecular Mapping Reveals Disease‐Specific Neurovascular Plasticity Underlying the Structure‐Pain Relationship

open access: yesAdvanced Science, EarlyView.
This study presents MUSIC, a novel immunostaining and clearing method coupled with large‐field light sheet microscopy, enabling 3D high‐resolution cellular and molecular mapping of intact musculoskeletal joints across species and joint types. Using joint degenerative and injury models, disease‐specific neurovascular alterations are uncovered, revealing
Peng Chen   +18 more
wiley   +1 more source
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Human Trafficking

Journal of Psychiatric Practice, 2018
Human sex trafficking, often referred to as modern-day slavery, is a major global human rights problem with at least 4.5 million people trafficked for commercial sex annually. Many of these women interface with the medical system regularly, often in women’s health clinics and the emergency departments.
Amy C, Brown, Christine E, Barron
  +7 more sources

Human Trafficking of Children

Pediatric Annals, 2020
Human trafficking has been increasingly recognized worldwide as a major public health problem. It is a crime based on exploitation of the most vulnerable and marginalized people of any community and is a violation of human rights. Children, especially immigrant and refugee children, are at risk of victimization and may experience considerable physical ...
Dena, Nazer, Jordan, Greenbaum
openaire   +2 more sources

Human Trafficking

Home Healthcare Now, 2017
Section I: Human Trafficking Explained 1. Introduction to Human Trafficking: Definitions and Prevalence (Burke) 2. Historical Perspective: Slavery over the Centuries (Newman) Section II: A Closer Look 3. Sociological Perspective: Underlying Causes (Cottingham, Nowak, Snyder, & Swauger) 4.
  +5 more sources

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