Results 291 to 300 of about 8,999,016 (386)

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley   +1 more source

Child protection from trafficking in humans

, 2005
Nevenka Žegarac
openalex   +2 more sources

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
wiley   +1 more source

Cell Biology of Membrane Trafficking in Human Disease

, 2006
Gareth Howell, Zoe G. Holloway, Christian Cobbold, Anthony P. Monaco, Sreenivasan Ponnambalam   +4 more
openalex   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking Pathways

, 2006
Jeremiah F. Roeth, Kathleen L. Collins
openalex   +1 more source

Switchable Bidirectional Sound Absorption Via Exceptional Point Modulation in Acoustic Metastructures with Interleaved Resonator Coupling

Advanced Science, EarlyView.
A switchable bidirectional acoustic metastructure is proposed, enabling broadband and frequency‐selective absorption via interleaved resonator coupling and exceptional point modulation. It outperforms traditional unidirectional designs, offering compact, efficient sound control from both directions and establishing a generalized framework for extending
Zichao Guo, Liangfen Du, Zirui Yang, Kexin Zeng, Ziping Lei, Zhonggang Wang, Zhendong Li, Zheng Fan   +7 more
wiley   +1 more source

Implementation of Section 11 of the Human Trafficking and Exploitation (Scotland) Act 2015: Independent Child Trafficking Guardians: Consultation Paper [PDF]

, 2019

core  

Single Mitochondrion Morphology‐Function Relationship Analysis Using Fluorescent Probes and Artificial Intelligence

Advanced Science, EarlyView.
An integrated strategy combining a mitochondria‐targeted fluorescent probe set and an AI framework enables simultaneous analysis of mitochondrial morphology and function at the single organelle level. By fusing multi‐parametric features, machine learning classification accurately distinguishes individual mitochondria under hypoxia‐related conditions ...
Yang Ding, Bin Fang, Qingzhe Li, Biying Zhang, Jintao Li, Hua Bai, Nicolas H. Voelcker, Bo Peng, Xuekang Yang, Lin Li   +9 more
wiley   +1 more source