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Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

Advanced Science, EarlyView.
This review summarizes recent advances in the spatiotemporal dynamics of the tumor microenvironment (TME). It highlights the roles of diverse immune and stromal cell populations, spatial architecture of the TME, as well as the gut and tumor microbiota in influencing responses to immune checkpoint inhibitors (ICIs), by integrating insights from single ...
Yuanyuan Zhang, Zhihua Liu
wiley   +1 more source

Comparative Single‐Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo

Advanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of river and swamp buffalo, encompassing 12 tissues and 397,011 cells, is constructed. Differential expression analyses identify metabolic and secretory tissues and cell types that mediate the divergence of milk production.
Dongmei Dai, Jingfang Si, Li Jiang, Bo Han, Kailai Wang, Xue Wang, Shihui Yan, Yichang Yin, Wei Chen, Huaming Mao, Alfredo Pauciullo, Shang‐Tong Li, Lingzhao Fang, Yi Zhang   +13 more
wiley   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms

Advanced Science, EarlyView.
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Ambra Da Ros, Maddalena Benetton, Giulia Borella, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez‐Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago, Franco Locatelli, Martina Pigazzi   +11 more
wiley   +1 more source

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Human Trafficking

Journal of Obstetric, Gynecologic & Neonatal Nursing, 2022
Human trafficking is an urgent contemporary human and labor rights issue. It is prevalent in a wide range of sectors, from the commercial sex sector to the construction industry to begging. Human trafficking also (increasingly) occurs in situations where the body is rendered ‘divisible,’ such as in cases of organ trafficking.
Alexandra Cheetham, I. Hurst
semanticscholar   +6 more sources

Human Trafficking

The Cambridge Handbook of Psychology and Human Rights, 2020
This chapter addresses human trafficking in four sections: the nature and extent of the harm; the structure of human trafficking (considered in terms of source, transit and market); regulation and control; and finally a discussion about human trafficking as illicit business. The definitions and common types of human trafficking are reviewed, along with
Nancy M. Sidun, Y. Flores
openaire   +2 more sources

Findings from the U.S. National Human Trafficking Hotline

Journal of Human Trafficking, 2021
Human trafficking is a public health crisis in the United States, yet it is difficult to understand national patterns and trends as official law enforcement data often suffer from reporting and identification issues.
Marie Skubak Tillyer, Michael R. Smith, R. Tillyer   +2 more
semanticscholar   +1 more source

COVID-19 and Human Trafficking-the Amplified Impact on Vulnerable Populations.

JAMA pediatrics, 2020
The coronavirus disease 2019 (COVID-19) pandemic has not only revealed inequities, it has also exacerbated them. Already-vulnerable populations are bearing the brunt of the health impacts of COVID-19 and also experiencing educational and economic ...
J. Todres, A. Diaz
semanticscholar   +1 more source