Results 111 to 120 of about 8,063,783 (304)

Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles [PDF]

, 2012
Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and ...
Joachim Jankowski, Antonia Vlahou (114470), Vlahou Antonia, Joachim Jankowski (114466), Ariela Benigni (114455), Kossida Sophia, Siwy, Justyna, Mullen, Wiliam, Bernd Mayer (32896), Perco, Paul, Perco, P., Wiliam Mullen (114460), Mischak Harald, Benigni, A., Carlamaria Zoja (114447), Mischak, H., Harald Mischak (103627), Sophia Kossida (113366), Benigni, Ariela, Bernd Mayer, Julie Klein, Justyna Siwy (103595), Klein Julie, Jankowski, J., Justyna Siwy, Kossida, Sophia, Mischak, Harald, Ferdinand H Bahlmann, Vlahou, Antonia, Stevens, Robert, Mayer, B., Zoja, C., Ferdinand H. Bahlmann (114474), Ariela Benigni, Benigni Ariela, Stevens Robert, Mayer Bernd, Kossida, S., Klein, Julie, Wiliam Mullen, Siwy, J., Bahlmann Ferdinand H., Paul Perco (32894), Jankowski, Joachim, Antonia Vlahou, Carlamaria Zoja, Sophia Kossida, Siwy Justyna, Stevens, R., Mullen Wiliam, Mullen, W., Robert Stevens, Zoja, Carlamaria, Perco Paul, Paul Perco, Bahlmann, F.H., Mayer, Bernd, Vlahou, A., Harald Mischak, Klein, J., Robert Stevens (18678), Julie Klein (114451), Bahlmann, Ferdinand H., Zoja Carlamaria, Jankowski Joachim   +64 more
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Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

New endogenous benzodiazepine receptor ligand in human urine: identity with endogenous monoamine oxidase inhibitor?

, 1983
Normal human urine contains both monoamine oxidase-inhibiting and benzodiazepine receptor-binding material. Each was extracted into ethyl acetate at pH 1 and subjected to high performance liquid chromatography: they ran similarly, showing three major ...
Armando, I., Glover, V., Sandler, M., Clow, A.   +3 more
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Correlation of total cholesterol and protein in urine in patients with the nephrotic syndrome [PDF]

, 1980
The excretion of protein and cholesterol in 24 h urine was measured in 42 patients with the nephrotic syndrome.
Wallner, J., Jüngst, Dieter, Karl, Hans Josef   +2 more
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Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]

, 2012
Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara, Hauck Stefanie M., Kerstin N. Euler, Barbara Amann, Dorsch Roswitha, Euler, K.N., Cornelia A Deeg, Dorsch, Roswitha, Roswitha Dorsch, Kerstin N Euler, Euler Kerstin N., Deeg Cornelia A., Amann Barbara, Treutlein, Gudrun, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Treutlein Gudrun, Hauck, Stefanie M., Euler, Kerstin N., Cornelia A. Deeg, Amann, B., Hartmann, Katrin, Hartmann Katrin, Hauck, S.M., Hartmann, K., Katrin Hartmann, Treutlein, G., Gudrun Treutlein, Deeg, C.A., Dorsch, R.   +30 more
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Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Human Elimination of Phthalate Compounds: Blood, Urine and Sweat (BUS) Study.

, 2012
Background. Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups. Multiple epidemiological studies have
Lobo, R., Genuis, S. J., Beesoon, S., Birkholz.D.   +3 more
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UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source

Evaluation of the expression of matrix metalloproteinase 9 and neutrophil gelatinase associated lipocalin in serum, urine and tumoral tissues of female dogs suffering from mammary gland tumors [PDF]

, 2013
In human medicine, it has been shown recently that the level of expression of matrix metalloproteinase-9 (MMP-9) and neutrophil gelatinase-associated lipocalin (NGAL) in serum, urine, and breast tissue were significantly increased in patients with breast
Belot, Guillaume
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