Results 61 to 70 of about 945,118 (264)

Human adaptation to adaptive machines converges to game-theoretic equilibria

open access: yesScientific Reports
Here we test three learning algorithms for machines playing general-sum games with human subjects. The algorithms enable the machine to select the outcome of the co-adaptive interaction from a constellation of game-theoretic equilibria in action and ...
Benjamin J. Chasnov   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Interaction Design Beyond the Product : Creating Technology-Enhanced Activity Spaces

open access: yes, 2012
The field of interaction design to date has been predominantly concerned with designing products, that is, devices, systems, and more recently services.
Kaptelinin, Victor,, Bannon, Liam J.,
core   +1 more source

From information behaviour research to the design of information systems: the Cognitive Work Analysis framework

open access: yesInformation Research: An International Electronic Journal, 2004
Cognitive Work Analysis (CWA) is a conceptual framework that makes it possible to analyze the forces that shape human-information interaction. This analysis can then be directly transformed to design requirements for information systems.
Raya Fidel, Annelise Mark Pejtersen
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Interaction and architectural space [PDF]

open access: yes, 2014
For many in the field of HCI, location and space are synonymous; yet, as we move from the mobile era to the ubiquitous era, computing becomes entangled with notions of space.
Mathew, Anijo   +17 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Establishing the design knowledge for emerging interaction platforms [PDF]

open access: yes, 2011
While awaiting a variety of innovative interactive products and services to appear in the market in the near future such as interactive tabletops, interactive TVs, public multi-touch walls, and other embedded appliances, this paper calls for preparation ...
Smeaton, Alan F., Lee, Hyowon
core  

Usability Work in Professional Website Design: Insights from Practitioners' Perspectives [PDF]

open access: yes, 2008
This exploratory study aims to gain insight into how usability practitioners work in professional web design. This is done through interviews and a grounded analysis.
Dominic Furniss   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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