Results 81 to 90 of about 945,118 (264)

Ergonomia degli artefatti cognitivi

Quaderni di Sociologia, 1993
People an work and in everyday life interact with different types of artifacts, that is tools that mimic and integrate human skills: technological artifacts that mimic physical human skills; organisational artifacts that mimic the human capacities to ...
Sebastiano Bagnara
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

‘Concrete Drawing’: An Ethnographical Study of Design, Matter and Affect

Ardeth, 2018
This paper looks critically at how design evolves through an interaction between human and non-human relations. We introduce different ways of understanding this by considering the mediating role that affect has on the design process.
Jan Smitheram, Akari Kidd
doaj  

Designing Human–Robot Collaborative Workstations: An ECS-Based Framework for Efficiency and Worker Empowerment

Machines
Human–robot collaborative workstations are increasingly deployed in industry, yet their design mainly focuses on productivity and ergonomics, with limited consideration of worker empowerment.
Malek Chakroun, Valérie Rocchi, Daniel Brissaud   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Teaching Design of Technologies for Collaborative Interaction in Physical, Digital, and Hybrid Spaces

, 2023
There is an increasing awareness of the importance of considering and mediating human collaboration in the design of technology. There are several research approaches focused on this, such as e.g., computer supported cooperative work (CSCW) and computer ...
Torgersson, Olof,, Ruijten, Peter,, Elif Baykal, Gökçe,, Hansen, Thomas Riisgaard,   +3 more
core  

Human-robot collaboration on an assembly work with extended cognition approach

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
In this study, the cognitive load that occurs in assembly works requiring human-robot collaboration is investigated. It is aimed to detect the effects of the workplaces designed with the approach of extended cognition on cognitive load and gender ...
Zeynep USTUNEL, Tulin GUNDUZ
doaj   +1 more source