Results 141 to 150 of about 146,849 (316)
, 2022 This chapter explores how humanitarianism navigates between resilience and vulnerability to set boundaries around what can and cannot be done in the name of humanitarian action. Humanitarianism has widely adopted a resilience approach, yet vulnerability remains a key indicator in targeting, although its application is increasingly complex.
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Health and Humanitarian Logistics - Panel 3: Matching Supply with Demand in Emergency Response
, 2016 Presented at the 8th Annual Conference on Health and Humanitarian Logistics, August 29-31, 2016, Atlanta, GA.Day 2 - Panel 3: Matching Supply with Demand in Emergency Response ; Moderated by Prashant YadavWolfgang Herbinger, Senior Advisor on Pandemic ...
McGhie, John +4 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Humanitarian Diplomatic Practices
, 2020 Humanitarian diplomacy is a new term, yet an old practice, and has received relatively little academic attention. This contrasts with the reality of humanitarian practitioners’ work, which has shown increasing interest in and use of the term ...
Turunen, Salla
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Humanitarian Accountability [PDF]
, 2006 Oxfam International understands that being accountable to beneficiaries of humanitarian aid requires more than statements. It requires the development of a number of practical mechanisms to ensure transparency and openness, and to ensure that all ...
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source