Results 161 to 170 of about 17,272 (218)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

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From Humanitarianism to Humanitarianization

2020
This chapter explains that much of contemporary international intervention takes places under the sign of humanitarianism. One of the most significant undertakings in postwar Bosnia and Herzegovina was the massive housing reconstruction projects run by international aid organizations as part of a highly politicized effort to move refugees back to their
openaire   +1 more source

Humanitarianism in surgery

Hernia, 2017
Humanitarianism is by definition a moral of kindness, benevolence and sympathy extended to all human beings. In our view as surgeons working in underserved countries, humanitarianism means performing the best operation in the best possible circumstances with high income country (HIC) results and training in-country surgeons to do the same.
Schroeder, A. D., Campanelli, G., Cavalli, M., Cusick, R., Fitzgibbons, R., Gilbert, A., Lawson, C., Manion, J., Matthews, B., Reinpold, W., Roll, S., Telemaque, L. -F., Wagner, J. P., Chen, D. C., Filipi, C. J.   +14 more
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Humanitarian Intervention

2022
The Elgar Encyclopedia of Human Rights is the most comprehensive reference work in the field of international human rights protection. Comprising over 340 entries, presented alphabetically, and available online and in print, the Encyclopedia addresses the full range of themes associated with the study and practice of human rights in the modern world ...
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The trouble with humanitarianism

Review of International Studies, 2007
ABSTRACTHumanitarianism – that is, the political, economic and military interference in the domestic affairs of a state justified by a nascent transnational morality – is one of the defining and most controversial features of the post-Cold War period.
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Humanitarian Intervention

2018
Abstract This chapter examines the ethical and political controversies that have accompanied humanitarian intervention (coercive interference by outside actors to address humanitarian suffering within the sovereign jurisdiction of a state).
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Humanitarian intervention

2015
Despite pronouncements that the age of humanitarian intervention was over (e.g. Cottey 2008), the 2011 NATO-led intervention in Libya has reignited debate about when, if ever, it is legitimate to use force to protect populations from mass killing, rape, forced displacement and other crimes which, as Michael Walzer (1977) put it, “shock the conscience ...
openaire   +3 more sources