Results 111 to 120 of about 281,579 (301)

Knowledge production in humanitarian crises: beware of the innovation trap

open access: yesThe Lancet Global Health, 2020
James Smith   +2 more
doaj   +1 more source

Managing Ethnic Conflict in Darfur: An Analysis of Third-Party Interventions [PDF]

open access: yes, 2018
Persistent ethnic conflict in Darfur has been met by third-party interventions with varying degrees of success. This paper seeks to isolate different methods of intervention in order to understand what types are effective in reducing the number of people
Dizney Swanson, Marley R.
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Integrating social sciences in community engagement in humanitarian action: benefits and challenges seen from the field

open access: yesJournal of International Humanitarian Action
The application of social sciences has been recognized as valuable to inclusive humanitarian programming that aims to be attentive to the needs and initiatives of affected communities.
Mandy Geise   +9 more
doaj   +1 more source

ASEAN and the non-traditional regional security agenda [PDF]

open access: yes, 2010
Without a doubt, the whole area of non-traditional security – whether it be threats, issues or challenges (the three are more or less used interchangeably in ASEAN statements and documents on the subject) – has come to occupy a prominent place on the ...
Rolls, Mark G.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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