Results 111 to 120 of about 26,381 (295)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Humanitarian action at Europe’s borders: Ambivalence, contestation and domestication under the European Pact on Migration and Asylum

Oñati Socio-Legal Series
This article examines the ambivalent role of professional humanitarian action at Europe’s borders, particularly along the EU’s southern Mediterranean border.
Cristina Churruca Muguruza
doaj   +1 more source

‘Localising’ humanitarian action: reflections on delivering women's rights-based and feminist services in an ongoing crisis

, 2019
This article shares the experiences of Women Now for Development, a women’s organisation working with Syrian women in Syria and neighbouring countries.
Patel, Champa, Al-Abdeh, Maria
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Mitigating gender-based violence risk in the context of COVID-19: lessons from humanitarian crises

BMJ Global Health, 2021
Vandana Sharma, Emily Ausubel, Christine Heckman, Erin Patrick, Dimple Save, Jocelyn T D Kelly   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Fresh Analysis of the Humanitarian System in Somaliland, Puntland and South Central Somalia: Somali state agencies and local organisations' capacities to manage humanitarian action [PDF]

, 2015
Where rain comes before humanitarian aid. In Somaliland, Puntland and South Central Somalia, the International Community is mixing its political interests with its humanitarian agenda. Insecurity severely hampers access in many parts, making it difficult
Almansa, Fernando
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Everyday Migrant Accompaniment: Humanitarian Border Diplomacy

, 2022
This article advances the notion of humanitarian border diplomacy, contributing to current academic discussions on humanitarian diplomacy and on the practice-theory nexus by conceptualising NGO s’ migrant accompaniment at borders as a form of ...
Churruca-Muguruza, Cristina
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source