Results 191 to 200 of about 22,657 (285)

Effectiveness and implementation of Self-Help Plus (SH+) and Doing What Matters in Times of Stress (DWMS): protocol of a systematic review and meta-analysis. [PDF]

BMJ Open
Thakur HK, Schäfer CG, Kunzler AM, Burmeister CF, Michael T, Equit M, Möhler E, Lieb K, Schäfer SK.   +8 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Humanitarian Intervention, Dirty Hands, and Deliberation [PDF]

Central European Journal of International & Security Studies, 2007
Charles A. Robinson
doaj  

Effectiveness of community-based mental health and psychosocial support through the Paracounsellor model for Rohingya refugees in Bangladesh. [PDF]

Public Health Pract (Oxf)
Iiyama S, Izutsu T, Miyamoto Y, Yesmin S, Begum T, Mariam E, Tsutsumi A.   +6 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Co-creating a decision-making framework for primary healthcare models in conflict-affected Cameroon and Nigeria. [PDF]

BMJ Glob Health
Omam LA, Alain M, Wudiri Z, Moustapha CA, Nuraini A, Asimiya SS, O'Laughlin KN, Ambebe R, Alfred J, Jarman E, Martin S, Njingu AE, Musa I, Fuen FM, Choupo L, Andu L, Manuel S, Acha-Morfaw O, Fuh CE, Nicholas T, Idrissou M, Mohammed H, Van Bortel T, Parkes-Ratanshi R.   +23 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluation of the METRA + intervention on mental health and social functioning in Afghan refugee adolescents in Pakistan: a pilot study. [PDF]

Eur J Psychotraumatol
Ahmadi SJ, Musavi Z, Farhat MW, Mehry S, Mcavoy D, Berzengi A, Brown A, Dainer-Best J, Jobson L.   +8 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Stakeholder perspectives on the WHO Mental Health Gap Action Programme Intervention Guide (mhGAP-IG) in humanitarian settings: a qualitative study in Lebanon and Iraq. [PDF]

Front Health Serv
Roriz de Queiroz M, Valente M, Hubloue I, Della Corte F.   +3 more
europepmc   +1 more source