Results 51 to 60 of about 14,586 (245)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Humanitarian intervention ; you need from prohibition [PDF]

open access: yesFaṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2004
مداخله بشر دوستانه از مفاهیمی است که باوجود دارا بودن سابقه‌ای حدودا یکصد ساله در ادبیات حقوق بین‌الملل،تنها در یک دهه اخیر مورد توجه مجامع بین‌المللی و از آن جمله محافل علمی و حقوقی جهان قرار گرفته است و دلیل آن،گسترش توجه‌ به حقوق بنیادین بشر از یک طرف
GHASEM AGHAII
doaj  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Exploring the Effectiveness of the Human Rights Court in Indonesia: A Call for Humanitarian Action

open access: yesJournal of Liberty and International Affairs
Indonesia’s Human Rights Court, established under Law No. 26/2000, has faced criticism due to persistent unresolved cases, highlighting flaws in its legal foundation.
Ria Wierma Putri   +2 more
doaj   +1 more source

Kosovo: the implications for humanitarian intervention [PDF]

open access: yesForced Migration Review, 1999
Do NATO’s actions represent an advance or a setback for international order?
Richard Caplan
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Sekuritisasi dalam Kerangka “R2P” dan Intervensi Kemanusiaan: Dilema Antara Legalitas dan Legitimasi

open access: yesJurnal Hubungan Internasional, 2015
The paper sets off by discussing security concept in IR and securitization process as well as new emerging norms in the frame of “R2P”. Furthermore, this paper also tries to examine closer at legal, ethic also other dilemmas by entering the discourse of ...
Eric Hendra
doaj   +1 more source

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