Results 71 to 80 of about 2,131,362 (279)

Exploring the Effectiveness of the Human Rights Court in Indonesia: A Call for Humanitarian Action

Journal of Liberty and International Affairs
Indonesia’s Human Rights Court, established under Law No. 26/2000, has faced criticism due to persistent unresolved cases, highlighting flaws in its legal foundation.
Ria Wierma Putri, Yunita Maya Putri, Eddy Rifai   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Kosovo: the implications for humanitarian intervention [PDF]

Forced Migration Review, 1999
Do NATO’s actions represent an advance or a setback for international order?
Richard Caplan
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Inconsistency in the implementation of the responsibility to protect during humanitarian crises: the case of Libya and Sudan. [PDF]

, 2014
Magister Legum - LLMThe aim of this mini-thesis is to examine the inconsistency in the implementation of the responsibility to protect (RTP) principle during armed conflicts with specific focus on the case of Libya and Darfur. Furthermore the mini-thesis
Nkosi, Mfundo
core   +2 more sources

Analyzing Humanitarian Intervention from an African Point of View

Vestnik RUDN. International Relations, 2012
The article analyzes the concept of humanitarian intervention from the African perspectives, owing to the none existed of agreed definition or codification of this concept in international law, it has continued to generate considerable interest among ...
- Okoh ThankGod Emeka
doaj  

Sekuritisasi dalam Kerangka “R2P” dan Intervensi Kemanusiaan: Dilema Antara Legalitas dan Legitimasi

Jurnal Hubungan Internasional, 2015
The paper sets off by discussing security concept in IR and securitization process as well as new emerging norms in the frame of “R2P”. Furthermore, this paper also tries to examine closer at legal, ethic also other dilemmas by entering the discourse of ...
Eric Hendra
doaj   +1 more source