Results 61 to 70 of about 1,488,327 (339)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Botanic gardens: Seizing the moment while imagining the future

Plants, People, Planet, 2022
Societal Impact Statement The coronavirus pandemic has reminded us that green spaces provide sanctuary and comfort, as well as opportunities for release and relief, during difficult times. However, to ensure continuing viability, botanical gardens can do
Peter Crane
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

HASS on the Hill [PDF]

, 2005
Deborah Henderson attended the Humanities, Arts and Social Sciences (HASS) on the Hill event as one of two NTEU Representatives. The NTEU has consistently supported the Council for the Humanities, Arts and Social Sciences (CHASS) as a peak body ...
Henderson, Deborah J.
core   +2 more sources

Crowdfunding in digital humanities: some evidence from Indonesian social enterprises

Aslib Journal of Information Management, 2020
PurposeThis article aims to understand how social enterprises adopt crowdfunding in digital humanities by investigating the mission drifting, risk sharing and human resource practices.Design/methodology/approachThis exploratory study uses a qualitative ...
A. Pratono, Delta Ardy Prima, N. Sinaga, A. Permatasari, Mintarti Ariani, Ling Han   +5 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The Crisis in the Humanities and its Relevance to Communication Studies

Anàlisi: Quaderns de Comunicació i Cultura, 2016
Contemporary pressures on institutions of higher learning, including economic pressures, a highly competitive “rankings” environment and critiques of the high cost of a university education, are making it increasingly more difficult to maintain a focus ...
Brett Ingram, Lisa Cuklanz
doaj   +1 more source

Capital par excellence: on money as an obscure thing

Estudios de Filosofía, 2020
Against the background of the contemporary debate about financialisation, the paper conceptualises the capitalist labour economy as fundamentally a monetary system.
Werner Bonefeld
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Watson’s Human Caring Theory: Pertinent Transpersonal and Humanities Concepts for Educators

Humanities, 2016
Jean Watson’s Theory of Human Caring and the caring moment are based in part in the concepts of transpersonal psychology. This paper will provide a historical background around transpersonal psychology and how it relates to Watson’s human caring moment ...
Carey S. Clark
doaj   +1 more source