Results 81 to 90 of about 1,304,045 (343)
FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl +2 more
wiley +1 more source
A Town Meeting on Energy : Prepared for Interior Alaskans [PDF]
, 1977 On March 26, 1977, an all-day Town Meeting on Energy was held at the Hutchison Career Development Center on Geist Road in Fairbanks, Alaska. This event was sponsored by the Alaska Humanities Forum in cooperation with the Fairbanks North Star Borough ...
Murray, Mayo, Seifert, Richard
core
FEBS Letters, Volume 599, Issue 8, Page 1113-1121, April 2025.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
, 2005 Deborah Henderson attended the Humanities, Arts and Social Sciences (HASS) on the Hill event as one of two NTEU Representatives. The NTEU has consistently supported the Council for the Humanities, Arts and Social Sciences (CHASS) as a peak body ...
Henderson, Deborah J.
core +2 more sources
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Introduction: Digital Humanities, Public Humanities
NANO, 2014 NANO: New American Notes Online: An Interdisciplinary Academic Journal for Big Ideas in a Small World. This special issue shows how both public and digital humanities research can be rendered more persuasive through engagement with cultures beyond the ...
Alex Christie +3 more
doaj
Context-aware Human Intent Inference for Improving Human Machine Cooperation [PDF]
arXiv, 2018 The ability of human beings to precisely recog- nize others intents is a significant mental activity in reasoning about actions, such as, what other people are doing and what they will do next. Recent research has revealed that human intents could be inferred by measuring human cognitive activities through heterogeneous body and brain sensors (e.g ...
arxiv
FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
Overview of International Household Panel Studies. Statement of the German Council of Science and Humanities on the Status and Future Development of the German Socio-Economic Panel (SOEP). November 13, 2009. Appendix 6 [PDF]
In July 2007, the German Federal Ministry of Education and Research (BMBF) requested that the German Council of Science and Humanities (Wissenschaftsrat) develop recommendations on improving Germany’s scientific infrastructure in the Humanities and ...
German Council of Science and Humanities
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