Results 41 to 50 of about 7,293 (262)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
How computers affected the humanities [PDF]
JCOM: Journal of Science Communication, 2002 This paper is concerned with the interactions between information technology and the humanities, and focuses on how the humanities have changed since adopting computers.
Salerno Emanuele
doaj
Social Networking Privacy—Who’s Stalking You?
Future Internet, 2015 This research investigates the privacy issues that exist on social networking sites. It is reasonable to assume that many Twitter users are unaware of the dangers of uploading a tweet to their timeline which can be seen by anyone.
Diane Gan, Lily R. Jenkins
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Semantic National Biography of Finland
Digital Humanities in the Nordic and Baltic Countries Publications, 2018 This paper presents the vision of publishing and utilizing textual biographies as Linked (Open) Data on the Semantic Web. As a case study, we publish the live stories of the National Biography of Finland, created by the Finnish Literature Society, as ...
Eero Hyvönen +4 more
doaj +1 more source
Building a Linked Open Data Portal of War Victims in Finland 1914–1922
Digital Humanities in the Nordic and Baltic Countries Publications, 2020 This paper presents results from a project that publishes data about the war victims in Finland in 1914–22 as a Linked Open Data service and a portal of tools called WARVICTIMSAMPO 1914–22 to explore and analyze the data.
Heikki Rantala +5 more
doaj +1 more source
Computer-Supported Human-Human Multilingual Communication
Interspeech 2007, 2007 Computers have become an essential part of modern life, providing services in a multiplicity of ways. Access to these services, however, comes at a price: human attention is bound and directed toward a technical artifact in a human-machine interaction setting at the expense of time and attention for other humans.
Waibel, Alex +2 more
openaire +2 more sources
Geographic human-computer interaction [PDF]
CHI '13 Extended Abstracts on Human Factors in Computing Systems, 2013 Geography is playing an increasingly important role in areas of HCI ranging from social computing to natural user interfaces. At the same time, research in geography has focused more and more on technology-mediated interaction with spatiotemporal phenomena.
Hecht, Brent +6 more
openaire +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source