Results 61 to 70 of about 7,293 (262)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Digital Medievalist, 2009 Melissa Terras's monograph deals with the complex process of reading ancient documents from a humanities computing perspective. The book focuses on the methodological and technical issues behind the implementation of a system that helps historians read ...
Arianna Ciula
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
dis-Covering the Early Modern Book: An Experiment in Humanities Computing
Digital Studies, 2009 None
Richard Cunningham
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Silencing in data science practices
Big Data & SocietyThis article examines the relationship between data science practices and epistemic injustice, with a particular focus on the phenomenon of silencing .
Ida Marie S Lassen +2 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Geocoding, Publishing, and Using Historical Places and Old Maps in Linked Data Applications
Digital Humanities in the Nordic and Baltic Countries Publications, 2018 This paper presents a Linked Open Data brokering service prototype Hipla.fi for using and maintaining historical place gazetteers and maps based on distributed SPARQL endpoints.
Esko Ikkala +2 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
SMA-Driven Assistive Hand for Rehabilitation Therapy
SensorsHome-based rehabilitation supports neuromuscular patients while minimising the need for extensive clinical supervision. Due to a growing number of stroke survivors, this approach appears to be more practical for patients across diverse demographics ...
Grace Mayhead +5 more
doaj +1 more source