Results 91 to 100 of about 312,819 (301)

Redaksi dan Pedoman Penulisan Jurnal Humanity, Vol 8, No. 1, September 2012

, 2014
Redaksi dan Pedoman Penulisan Jurnal Humanity, Vol 8, No.
Pedoman Penulisan, Redaksi &
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Consumers' values and preferences for long-term policies in multifaceted rice production and consumption: a deliberative experiment incorporating the perspective of future generations in 2050

Global Sustainability
Non-technical summary The design of food systems is a common theme that requires stakeholders to prioritize long-term perspectives and balance between benefits for the present and future generations. Building on this theme, this study aims to demonstrate
Yoshinori Nakagawa, Kentaro Hayashi, Takaharu Kameoka, Hiroki Sasaki, Koichi Kuriyama, Masako Ichihara, Makoto Saiki, Tatsuyoshi Saijo   +7 more
doaj   +1 more source

Effects of Exercise Intensities on Alterations of Surface and Core Temperature, and Physiological Metabolic Variables [PDF]

운동과학
PURPOSE The relationship between core and surface body temperatures should be elucidated under various exercise conditions. This study investigated whether body temperature patterns were differentially regulated between body surface area (Tbs) and ...
정명 김, 선철 강, 관훈 김, 경준 안, 종삼 이   +4 more
doaj   +1 more source

Redaksi dan Pedoman Jurnal Humanity Vol. 9, No.1, September 2013

, 2015
Redaksi dan Pedoman  Jurnal Humanity Vol.
& Pedoman, Redaksi
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Diversion ostomy improves treatment tolerance, conversion surgery, and survival compared with self-expanding metal stenting in initially unresectable obstructive colorectal cancer

Frontiers in Oncology
BackgroundThe optimal decompression strategy for patients with initially non-resectable obstructive colorectal cancer undergoing conversion intent treatment remains unclear.
Fengbin Cai, Weiming Jiang, Huali Cai, Bo Hu   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source