Results 141 to 150 of about 312,819 (301)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Crimes Against Humanity. Emergence of a law of humanity

open access: yes, 2012
A legal analysis of crimes against humanity. Examines the emergence of the norms that make up crimes against humanity in a historical context, with particular attention to the Nuremberg proceedings, and establishes a content for such crimes with ...
Garðar Steinn Ólafsson 1983-
core   +1 more source

Daftar Isi, JURNAL HUMANITY, ISSN: 0216-8995 Volume 8, Nomor 1, September 2012

open access: yes, 2014
JURNAL HUMANITY, ISSN: 0216-8995 Volume 8, Nomor 1, September 2012 Model Pembelajaran Pendidikan Karakter pada Pembelajaran Tematik di SD Muhammadiyah 9 Kota Malang Dyah Worowirastri Ekowati1, Rina Wahyu Setyaningrum2, Husamah3.
Isi, Daftar
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

open access: yesFEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Daftar Isi. JURNAL HUMANITY, ISSN: 0216-8995 Volume 8, Nomor 2, Maret 2013

open access: yes, 2014
Daftar Isi. JURNAL HUMANITY, ISSN: 0216-8995  Volume 8, Nomor 2, Maret 2013ModelKebijakan Pembangunan Daerah Tertinggal Studi Kasus di Kabupaten Supiori ProvinsiPapuaAbd.
Isi, Daftar
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Crimes Against Humanity

open access: yes, 2018
Professor Sean D. Murphy, of the George Washington University School of Law, presented a draft of his work Crimes Against Humanity. This paper examines the prevention and punishment of crimes against humanity.
Murphy, Sean D.
core   +1 more source

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