Results 201 to 210 of about 23,799 (303)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Clinical translation of TLR agonist-modified silicified cancer cell therapy supported by humanized mouse models. [PDF]

Mol Ther Oncol
Steinkamp MP, Burke D, Morrison M, Lagutina I, Fitzpatrick L, Serda RE.   +5 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Humanization of care in Primary Health Care: social representations of people with pulmonary tuberculosis. [PDF]

Rev Esc Enferm USP
Pacheco MDA, Palmeira IP, Ferreira MA, Soares AS, Andrade EGR, Pereira AA, Rodrigues ILA, Matos WDV.   +7 more
europepmc   +1 more source

Membership‐Making in Diverse Societies: Revisiting the Idea of Society as a Common Possession

Journal of Applied Philosophy, EarlyView.
ABSTRACT The traditional aim of Western social democracy has been to create a society that is a ‘common possession’ of its members (in T.H. Marshall's words). Social democratic politics has therefore been both society‐making and membership‐making, orienting people to a shared society as an object of attachment and loyalty, and nurturing membership ...
Will Kymlicka
wiley   +1 more source

Intergroup Meta-Respect Perceptions in a Context of Conflict. [PDF]

Behav Sci (Basel)
Nasie M.
europepmc   +1 more source

Against Dualism: Border Regimes, the International Order, and Domestic Social Relations

Journal of Applied Philosophy, EarlyView.
ABSTRACT In this response to Will Kymlicka, I reflect upon whether dualist politics – a separation of the domestic and the international – hinders our understanding of how to create inclusive and solidaristic societies. Using the example of border regimes, I suggest that the structure of the international order, of which such regimes are part ...
Clara Sandelind
wiley   +1 more source

Application of the humanized mouse model in research into SARS-CoV-2 infection (Review). [PDF]

Med Int (Lond)
Feng X, Wang Y, Li Y, Long J, Liu F, Yang H.   +5 more
europepmc   +1 more source

Humans--a threat to humanity.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2008
openaire   +2 more sources