Results 201 to 210 of about 61,570 (310)

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci. [PDF]

Nat Commun
Taguchi J, Kikuchi M, Jeon H, Shimizu R, Mori H, Ikawa M, Yamada Y, Sato K, Ikeda T, Yamazaki S, Ozawa M.   +10 more
europepmc   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow. [PDF]

Proc Natl Acad Sci U S A
Sefik E, Philbrick W, Zhang F, Agrawal K, Van Lee B, Sam J, Karatepe K, Zheng Y, Liang K, Peng S, Mirza H, Rangavajhula A, Simon P, Arun N, Babu P, Eynon E, Chiorazzi M, Shan L, Halene S, Luo HR, Rongvaux A, Kluger Y, Flavell RA.   +22 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Healthcare Professionals' Perceptions of Patients' Out-of-ICU Activities: Exploring Opportunities for Humanizing ICU Care. [PDF]

J Patient Exp
Sasano N, Yasuda M, Takahashi R, Uehara T.   +3 more
europepmc   +1 more source

“Train and Hope”: The Role of Restorative Justice Coordinators in Sustaining a Culture of Care in Schools

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This article examines the role of restorative justice coordinators in supporting teachers and schools in adopting a whole‐school approach to restorative justice in education. Coordinators are often tasked with implementing a train‐and‐hope model, in which they receive initial training in restorative justice but are largely left unsupported ...
Crystena Parker‐Shandal, Kristina R. Llewellyn, Sandeep Manku, Mackenzie Leclaire   +3 more
wiley   +1 more source

Model selection in preclinical nucleic acid therapeutics research. [PDF]

Commun Biol
Oliver PL, Hill AC.
europepmc   +1 more source

Digital Transformation in Work Integration Social Enterprises: Leadership Strategies and the Role of Internal Stakeholders

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Digital transformation is increasingly reshaping how social enterprises organize work, engage stakeholders, and pursue social value. While prior research has examined digitalization in hybrid organizations, limited attention has been paid to how responsibility for inclusive digital transformation is enacted internally.
Riccardo Maiolini, Federica D’Alessandro, Paolo Landoni   +2 more
wiley   +1 more source

Framework humanization enhances GM3(Neu5Gc)-targeting CAR-T cell function by reducing tonic signaling. [PDF]

Front Immunol
Tu J, Li X, Zhu Y, Li S, Zhang G, He Y, Zhang C, Lu Z.   +7 more
europepmc   +1 more source