Results 181 to 190 of about 23,799 (303)

Recovery-oriented practices as a pathway toward advancing mental healthcare in Brazil. [PDF]

Cad Saude Publica
Souza LM, Silva TRD, Farkas M, Russinova Z, Andrade MCR.   +4 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Low‐Concentration Dopamine Potentiates Gastric Motility Through Activation of Dopamine D5 Receptor on Enteric Cholinergic Neurons

Gut Medicine, EarlyView.
ABSTRACT Background Dopamine (DA) exerts complex concentration‐dependent effects on gastrointestinal motility. Although its inhibitory action through D2‐like receptors is well‐established, the mechanisms underlying its excitatory effects remain elusive.
Xiao‐Li Zhang, Tuo Ji, Yue Zhang, Cai‐Feng Zhang, Yun‐Jing Bai, Jin Song   +5 more
wiley   +1 more source

Development and <i>in vivo</i> evaluation of novel humanized CD19 CAR-T cells for advanced B cell malignancies. [PDF]

Front Immunol
Andrade CO, Bezerra MRL, Sousa IG, Correia EM, Lima AJF, Abdo L, Aragão EAA, Araujo RPDS, Pinheiro DP, Studart IC, Steimbach JV, Pretti MA, Furtado GP, Lourenzoni MR, Brigido MM, Maranhão AQ, Bonamino MH.   +16 more
europepmc   +1 more source

Humanized Antibodies Targeting Ectodomains of IL-6R and GP130 Suppress IL-6/STAT3 Signalling and Tumour Growth in Breast Cancer Models. [PDF]

J Cell Mol Med
Pereira SD, Baipadithaya G, Prasad K, Naha R, Acharya LP, Gopalakishna GPU, Periasamy R, Chandrashekar A, Bhat S, Joshi MB, Satyamoorthy K.   +10 more
europepmc   +1 more source

HuAbDiffusion: a discrete language diffusion model used for antibody humanization. [PDF]

Brief Bioinform
Liu D, Hao X, Fan L.
europepmc   +1 more source

Open-Door ICU Model and Humanized Care: A Systematic Review. [PDF]

Nurs Rep
Duque PA, Quintero Duque S.
europepmc   +1 more source

Mental Health Nurses' Perceived Appropriateness of Coercive Measures and Security Technologies in Psychiatric Settings: A National Cross-Sectional Study. [PDF]

J Nurs Scholarsh
Anastasi G, Latina R, Longobucco Y, Stievano A, Bambi S.   +4 more
europepmc   +1 more source

Partnerships for Social Cohesion and Social Impact: How Corporate‐Community Co‐Development Constitutes an Impactful HR Initiative

Human Resource Management, EarlyView.
ABSTRACT Organizational scholars have begun to recognize the importance of social cohesion, but we know little about how it can lead to broader social impact, and even less about the role of human resource management (HRM) in these processes. To investigate this link, we examined corporate community co‐development as a particularly impactful HRM ...
Cristina B. Gibson, Jennifer Gibbs, Nitzan Navick, Kimberly McGinnis   +3 more
wiley   +1 more source