Results 171 to 180 of about 61,570 (310)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

HuAbDiffusion: a discrete language diffusion model used for antibody humanization. [PDF]

Brief Bioinform
Liu D, Hao X, Fan L.
europepmc   +1 more source

Сутнісна характеристика соціально-економічної категорії „трудовий потенціал сільської місцевості”

, 2013
The main existing approaches to the interpretation of the term "labour potential", "labour potential of rural areas," were considered. The new interpretation of the concept of "labour potential of rural areas" was suggested.
Kovalenko, Snejana, Коваленко, С. В.   +1 more
core  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Open-Door ICU Model and Humanized Care: A Systematic Review. [PDF]

Nurs Rep
Duque PA, Quintero Duque S.
europepmc   +1 more source

Human-human and human-animal interaction

, 2010
The aim of the present thesis was to investigate hormonal and physiological effects in mothers during a breastfeeding session and in dogs and their owners in response to short-term interaction. In study one, sixty-six mothers receiving either exogenous oxytocin infusion and/or epidural analgesia (EDA) during labor or intramuscular oxytocin injection ...
openaire   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Impact of an integral accompaniment program on undergraduate students' self-perception of transversal competence development: a quasi-experimental study. [PDF]

Front Psychol
Crespí P, Álvarez-Montero S, Faná Del Valle Villar A, Santos C, Castañeda-Vozmediano R.   +4 more
europepmc   +1 more source

Report drawn up on behalf of the Committee on the Environment, Public Health and Consumer Protection on the First Report by the Commission of the European Communities on the State of the Environment. EP Working Documents, document 468/77, 10 January 1978 [PDF]

, 1978
Baas, J.
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