Results 161 to 170 of about 23,799 (303)

Age-related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome. [PDF]

Alzheimers Dement
Baniowska MR, Mumford P, Prestia F, Stephan P, Beament M, Birling MC, Lanzillotta C, Ciafardini L, Barone E, Lau G, Chevalier C, Nahy C, Messaddeq N, Lestra T, Wu Y, Nalesso V, Di Domenico F, Wiseman F, Herault Y.   +18 more
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

A side-by-side biophysical comparison of five single-domain antibody scaffolds used for synthetic display libraries. [PDF]

J Biol Chem
Rauschmayer M, Abdellatif M, Chubanova A, Leonardi N, Preinsberger AB, Schwach J, Stengl A.   +6 more
europepmc   +1 more source

Humanization as a Phenomenon of Post-bipolar International Relations System

, 2018
This work studies theoretical problems of international relations development in conditions of globalization. Main factors of humanization of current international relations system are characterized.
Sarsenov, M. B., Raev, D. S.
core  

The Global Humanization Event (GHE)

The recent rejection of the "Anthropocene Series/Epoch," as proposed by the Anthropocene Working Group (AWG), by the International Commission on Stratigraphy (ICS) and the International Union of Geological Sciences (IUGS), has reopened discussion about ...
Rull, Valentí
core   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Development of advanced humanized models: The future of pre-clinical testing of immune therapies? [PDF]

Mol Ther Oncol
Bayliss RJ.
europepmc   +1 more source

Brand Humanization

This paper examines the impact Brand Humanization has, when brands use it on social mediaplatforms. The main focus is to understand how young people perceive the phenomenon, andhow it affects their relation to the brands that utilize this strategy.The ...
Reisby, Peter Bjørn, Bjerregaard, Jens Lundager, Pardorf-Petersen, Augustine, Kohlmets, Sylvester Glerup, Rubinstein, Michala Petrovna, Krebs, Christina Laurberg, Sjøgren, Rasmus   +6 more
core  

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Conceptualizing the Humanized Hospital: A Multidimensional Textual Data Analysis from Undergraduate Nursing Students' Perspectives. [PDF]

Nurs Rep
Lo Monaco M, Littlemouse G, Anastasi G, Gheorghe R, Latina R, Figura M.   +5 more
europepmc   +1 more source