Results 91 to 100 of about 2,615 (266)

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source

Hospital care at childbirth: social representations of women and health care professionals / Assistência ao parto na maternidade: representações sociais de mulheres assistidas e profissionais de saúde

Psicologia: Reflexão e Crítica, 2010
The aim of this comparative study was to investigate social representations of assisted women (20) and health care professionals (20) concerning childbirth assistance in maternities.
Sandra Cristina da Silveira, Brígido Vizeu Camargo, Maria Aparecida Crepaldi   +2 more
doaj  

Ungraduate students view on the presence of clown-doctors at the University Hospital [PDF]

Revista Brasileira em Promoção da Saúde, 2012
Objectives: To understand how students perceive the humanization of health, as well as the contributions of Project Y “clown doctors” in academic and hospital routine, identifying the relevance of this group through the construction of new paradigms ...
Gabriela Maia Mota, Daniel Magalhães Coutinho Mota, Márcia Maria Tavares Machado, Rebecca Holanda Arrais, Carla Pires Vieira de Oliveira, Melissa do Santos Salgado, Miliany Michelly Barreto de Souza, Lorena de Holanda William   +7 more
doaj  

B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source

Freedom dreaming of migrant justice: Critical reflections on counterspaces and institutional violence in the university

American Journal of Community Psychology, EarlyView.
Abstract US universities are built on stolen land and sustained through hierarchies of power that produce what migrant justice scholars name as b/order regimes. As institutions that claim to be sites of learning and inclusion, universities are fraught with contradictions as simultaneously sites of dispossession, exclusion, and control.
Sara L. Buckingham, Jesica Siham Fernández   +1 more
wiley   +1 more source

Pharmaceutical Care and humanization of care: lessons from the promotion of adhesion to therapeutic care of users in chronic conditions

O Mundo da Saúde, 2012
The high consumption of drugs is increasingly making health professionals be concerned about adherence to treatment by patients. This article aims to share experiences in pharmaceutical care performed by a Basic Health Unit (BHU) in São Paulo.
Pollyana Borges de Araújo Prata, Marcia Regina Cunha, Érica Gomes Pereira, Lucia Yasuko Izumi Nichiata   +3 more
doaj  

Immigration detention centers as torturing environments: Ethical reckonings, radical refusals, and implications for a psychology of resistance

American Journal of Community Psychology, EarlyView.
Abstract This paper examines psychologists' ethical dilemmas in immigration detention centers. Using critical psychology, border, and detention scholarship, it highlights psychologists' historical complicity in state violence, from the U.S. Enhanced Interrogation Program to current border regimes.
Francesca Esposito, Federica de Cordova, Julia Manek, Sara Buckingham, Camilla Ponti, Francesco Tommasi, Bradley Olson   +6 more
wiley   +1 more source

Humanização do cuidado de enfermagem: o que é isso?

Revista Brasileira de Enfermagem
Este estudo objetivou conhecer o significado que profissionais da enfermagem atribuem ao termo "humanização" e verificar como o empregam no desenvolvimento de suas atividades. A pesquisa é de natureza qualitativa, realizada por meio do método da história
Nilza Maria de Souza Corbani, Ana Cristina Passarela Brêtas, Maria Clara Cassuli Matheus   +2 more
doaj