Results 181 to 190 of about 2,615 (266)

Interpreting mental health experiences in disaster settings: a qualitative analysis of medical students' reflective narratives during flood response in Thailand. [PDF]

BMC Psychol
Disro S, Pitanupong J, Woonkaew W.
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Targeting cancer expressed EGFR with a humanized monoclonal antibody. [PDF]

Sci Rep
Costa TGF, Sarnovsky R, Zhan J, Maslanka CA, Obiorah I, Xia D, FitzGerald D, Antignani A.   +7 more
europepmc   +1 more source

Validation of the Spanish Short Version of the Perception of Humanized Care Behaviors Scale in Hospitalized Adults in Chile. [PDF]

Invest Educ Enferm
Cuadros-Carlesi KM, Henríquez-Roldán CF, Ruiz-Araya PA, Alvarado San Román XR, Oyarce Quiroz MR, Vásquez Osses MA.   +5 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Defining the Patient Journey and Identifying Digital Health Solutions in Treatment-Resistant Schizophrenia. [PDF]

Actas Esp Psiquiatr
Grasa E, Forment A, Alonso-Solís A, Ramalho L, Roldán A, Pousa E, Aussó S, Berdun J, Genova Tesoro A, Escudero J, Corripio I.   +10 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Persistence in Human-Voice Assistant Interaction.

Voice assistants help humans with tasks like scheduling meetings by providing an interface in the most natural modality, speech. Being a fundamental mechanism in human-human interaction, persistence – the tendency for interlocutors to converge linguistically when interacting – has been shown to be equally pervasive in interaction with machines, and ...
openaire   +2 more sources

CRISPR-mediated precise large fragment insertion in zygotes enables rapid generation of humanized immunoglobulin heavy-chain mice. [PDF]

Immunity
Nair U, Akauliya M, Warner JE, Parikh S, Ronsard L, Ssozi M, Rays Wahba L, Esposito AG, Kelley B, McCarthy C, Weldon SR, Wu L, Lingwood D, Batista FD.   +13 more
europepmc   +1 more source