Results 191 to 200 of about 15,172 (358)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Editorial: Distributed training and rural health professions education. [PDF]

Front Med (Lausanne)
Strasser RP, Wright J, Abdalla ME, Van Schaik L, Muller JV.   +4 more
europepmc   +1 more source

Logos, ethos and pathos in balance [PDF]

, 2014
Fuller, Jonathan
core  

PBMC-engrafted humanized mice models for evaluating immune-related and anticancer drug delivery systems [PDF]

Yoshie Kametani, Ryoji Ito, Yoshiyuki Manabe, Jerzy K. Kulski, Toshiro Seki, Hitoshi Ishimoto, Takashi Shiina   +6 more
openalex   +1 more source

Connecting with the community-experiences of medical students doing homestays in rural South Africa. [PDF]

Front Med (Lausanne)
Gaede B.
europepmc   +1 more source

Right from the Start, Applying Anthropology with Lower Division Students [PDF]

, 2009
English-Lueck, Jan
core   +1 more source

The Hairless Mutation Hypothesis: a Driving Force of Humanization by Enforcing Bipedalism to Hold a Baby, by Allowing Immature Baby Delivery to Enlarge the Brain after Birth, and by Making Use of Fire to Get Meat and to Cook Foods

, 2014
Shizuyo Sutou
openalex   +2 more sources

A failed transplant

Journal of Hospital Medicine, EarlyView.
David L. Curtis
wiley   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, EarlyView.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Care Beyond Cure: Humanizing the Intensive Care Unit Journey. [PDF]

Indian J Crit Care Med
Chacko B.
europepmc   +1 more source