Results 111 to 120 of about 174,519 (291)
Animal Interface: Digital Design beyond the Humankind
Галактика медиа: журнал медиа исследованийHumankind has always coexisted with other species: its mimetic features and abilities, which include science and art, as well as the graphical user interface that appears at their intersection, express empathy, understanding, premonition, receptivity and
Konstantin A. Ocheretyany
doaj +1 more source
Sovereign Nothingness: Pyotr Chaadaev's Political Theology [PDF]
, 2019 This paper speculatively reconstructs the unique intervention that Pyotr Chaadaev, the early nineteenth-century Russian thinker, made into the political-theological debate.
Chepurin, Kirill, Dubilet, Alex
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The politics of human nature [PDF]
, 2016 Human nature is a concept that transgresses the boundary between science and society and between fact and value. It is as much a political concept as it is a scientific one.
Kronfeldner, Maria
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Laminar Ulva Species: A Multi-Tool for Humankind?
Applied SciencesGreen algae, phylum Chlorophyta, due to their green appearance as higher plants, are seen as one of the raw materials to be widely used by humanity for different purposes. How can these different purposes achieve ONU Sustainable Development Goals?
Sofia Pereira Costa +2 more
doaj +1 more source