Results 201 to 210 of about 68,675 (252)
Chemistry – A European Journal, EarlyView.The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma +13 more
wiley +1 more source
Fluorogenic Sydnones for Bioorthogonal Labeling of DNA
Chemistry – A European Journal, EarlyView.Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller +1 more
wiley +1 more source
Fish Scales: A Multifunctional Biomaterial from Nature
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.A lightweight hybrid backpack integrating SC‐TENGs and R‐EMGs harvests biomechanical energy during walking. With a low activation speed of 3 km h−1 and a high specific power of 0.18 W kg−1, it enables self‐powered field safety management. The power backpack refers to an energy‐harvesting solution engineered to mitigate battery reliance in wearable ...
Jie Chen +6 more
wiley +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Streptococcus equi subspecies zooepidemicus is a highly diverse opportunistic pathogen of horses, associated with respiratory disease and endometritis. Objectives To characterise S. zooepidemicus isolates recovered from young ponies during a natural episode of respiratory disease, and to determine if vaccination with Strangvac®, a ...
Romain Paillot +8 more
wiley +1 more source
Exploration, EarlyView.There is no effective method to treat this virus and prevent its transmission. To address this, we have developed a nano‐silver‐selenium liquid dressing (AgSe@LD) by combining silver and selenium nanoparticles with commercial liquid dressings. This unique AgSe@LD formulation exhibits good adhesion, stability and toughness and demonstrates efficient ...
Wei Wang +15 more
wiley +1 more source
Recent Progress on Graphitic Carbon Nitride–Based Photocatalysts for Hydrogen Peroxide Synthesis
Exploration, EarlyView.This review summarizes recent progress in using graphitic carbon nitride (g‐C3N4) photocatalysts to produce hydrogen peroxide (H2O2). It highlights how solar energy can cleanly convert water and oxygen into this valuable chemical. We discuss key modification strategies, such as defect engineering, doping, and junction construction, to enhance ...
Liangpang Xu, Xixian Nan, Jimmy C. Yu
wiley +1 more source
Exploration, EarlyView.Schematic illustration of the effect of microneedles incorporating cerium‐based MOF loading dihydrocapsaicin (MN‐MOF@DHC) to scavenge reactive oxygen species (ROS) generation, beanti‐inflammatory, inhibit the apoptosis of endothelial cells (ECs), promote angiogenesis, and accelerate diabetic wound healing. ABSTRACT Diabetic foot ulcers (DFUs) present a
Yuxu Wu +11 more
wiley +1 more source
Exploration, EarlyView.We developed a dissolvable microneedle patch that locally delivers a radiolabeled coordination polymer designed to simultaneously destroy tumor cells and stimulate antitumor immunity through STING activation and pyroptosis. This strategy significantly inhibited melanoma growth and improved the effectiveness of immune checkpoint therapy, highlighting a ...
Pian Yu +12 more
wiley +1 more source
FlexMat, EarlyView.A novel two‐dimensional heterojunction assembled from graphene oxide and exfoliated black phosphorus via van der Waals interactions is proposed to replace widely used poly(3,4‐ethylenedioxythiophene)‐polystyrene sulfonate for efficient hole injection layer in organic light‐emitting diodes, achieving impressive electroluminescence performance.
Yuefeng Li +9 more
wiley +1 more source