Chloromethylisothiazolinone induces ER stress-induced stress granule formation in human keratinocytes [PDF]
Animal Cells and Systems, 2023 Chloromethylisothiazolinone (CMIT), a humidifier disinfectant, is known to be toxic to the respiratory system. While the toxic effect of CMIT on the lungs has been widely investigated, its effect on the skin is well unknown.
Kee K Kim, Eun-Mi Kim
exaly +7 more sources
A Study on the Behavior Patterns of Liquid Aerosols Using Disinfectant Chloromethylisothiazolinone/Methylisothiazolinone Solution [PDF]
Molecules, 2021 This study evaluates the behavioral characteristics of components (methylisothiazolinone (MIT) and chloromethylisothiazolinone (CMIT)) contained in disinfectant solutions when they convert to liquid aerosols.
Yong-Hyun Kim +2 more
exaly +8 more sources
Polyhexamethylene guanidine phosphate, chloromethylisothiazolinone, and particulate matter are dispensable for stress granule formation in human airway epithelial cells [PDF]
Animal Cells and Systems, 2021 Environmental risk factors are recognized as threats to public health. Stress granules (SGs) are non-membranous assemblies of mRNAs and proteins expressed in response to various stressors to promote cell survival. In this study, SG formation was examined
Seri Choi, Kee K Kim, Eun-Mi Kim
exaly +7 more sources
Absence of Adverse Effects on Pulmonary Histopathology and Functions Following Inhalation Exposure to Chloromethylisothiazolinone/Methylisothiazolinone [PDF]
ToxicsIn South Korea, issues have been raised regarding exposure to humidifier disinfectant products containing certain chemicals postulated to induce lung diseases in consumers.
Esref Demir
exaly +7 more sources
Environment International, 2022 A variety of isothiazolinone-containing small molecules have been registered and used as chemical additives in many household products. However, their biodistribution and potential harmful effects on human health, especially respiratory effects, were not
Mi-Kyung Song +2 more
exaly +6 more sources
Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children [PDF]
PLoS ONE, 2017 Children who were only exposed to a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) as humidifier disinfectant (HD) components were evaluated for humidifier disinfectant-associated lung injury (HDLI) from 2012.
Hyun-Ju Cho, Dong-Uk Park, Jisun Yoon
exaly +6 more sources
Characteristics of Exposure to Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) among Humidifier Disinfectant-Associated Lung Injury (HDLI) Patients in South Korea [PDF]
Molecules, 2020 This study aimed to quantify both chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) dissolved in different product brands and to characterize the exposure to these chemicals among humidifier disinfectant-associated lung injury (HDLI ...
Dong-Uk Park, Jiwon Kim, Ju-Hyun Park
exaly +6 more sources
Ecotoxicology and Environmental SafetyMouse strain and sex variability may provide a better understanding of the isothiazolinone-associated respiratory toxicity profile; however, this remains poorly understood.
Mi-Kyung Song +2 more
exaly +6 more sources
MTF1 Is Essential for the Expression of MT1B, MT1F, MT1G, and MT1H Induced by PHMG, but Not CMIT, in the Human Pulmonary Alveolar Epithelial Cells [PDF]
Toxics, 2021 The inhalation of humidifier disinfectants (HDs) is linked to HD-associated lung injury (HDLI). Polyhexamethylene guanidine (PHMG) is significantly involved in HDLI, but the correlation between chloromethylisothiazolinone (CMIT) and HDLI remains ...
Sang-Hoon Jeong +13 more
doaj +3 more sources
New data on the metabolism of chloromethylisothiazolinone and methylisothiazolinone in human volunteers after oral dosage: excretion kinetics of a urinary mercapturic acid metabolite ("M-12"). [PDF]
Arch Toxicol, 2021 AbstractMethylisothiazolinone (MI) as well as the mixture of chloromethylisothiazolinone/methylisothiazolinone [MCI/MI (3:1)] are biocides that are used in a variety of products of every-day life. Due to the skin sensitizing properties of these biocides, their use has come under scrutiny.
Schettgen T, Bertram J, Kraus T.
europepmc +7 more sources