Toxics, 2021 The inhalation of humidifier disinfectants (HDs) is linked to HD-associated lung injury (HDLI). Polyhexamethylene guanidine (PHMG) is significantly involved in HDLI, but the correlation between chloromethylisothiazolinone (CMIT) and HDLI remains ...
Sang-Hoon Jeong +13 more
doaj +2 more sources
Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model [PDF]
Scientific Reports, 2020 AbstractExposure to chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) has been associated with allergic contact dermatitis and occupational asthma. Despite this association however, no study has investigated the effects of CMIT/MIT exposure on the development of atopic dermatitis (AD). This study was conducted to investigate the influence of
Go, Han-Na +6 more
openaire +3 more sources
Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury
Journal of Korean Medical Science, 2018 Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries.
Eun Lee +10 more
openaire +3 more sources
Molecules, 2020 Currently available toxicity data on humidifier disinfectants are primarily limited to polyhexamethylene guanidine phosphate-induced lung fibrosis.
Mi-Kyung Song, Dong Im Kim, Kyuhong Lee
doaj +2 more sources
A comprehensive study of deaths due to exposure to humidifier disinfectant in Korea: focusing on medical records, assessment of exposure to humidifier disinfectants, and causes of death [PDF]
Epidemiology and Health, 2021 OBJECTIVES We aimed to determine the characteristics of the deceased victims of deaths caused by exposure to humidifier disinfectants, and present the distribution of the victims’ data submitted for damage application, demographic characteristics ...
Yeong Jun Ju +5 more
doaj +3 more sources
Molecules, 2021 In recent decades, demands for novel insecticides against mosquitoes are soaring, yet candidate chemicals with desirable properties are limited. Kathon is a broad-spectrum isothiazolinone microbicide, but other applications remain uncharacterized. First,
Wen-Ze He +5 more
doaj +2 more sources
Identification and Determination of Methylisothiazolinone and Chloromethylisothiazolinone in Cosmetics by Liquid Chromatography Tandem Mass Spectrometry [PDF]
Indonesian Journal of PharmacyBroad-spectrum preservatives known as isothiazolinone biocides are frequently found in cosmetic, industrial, and household products. Certain isothiazolinones (methylisothiazolinone, MIT, and chloromethylisothiazolinone, CMIT) might result in eczema, edema, or allergic contact dermatitis by dermal contact or inhalation.
Yustina Yustina +3 more
openaire +2 more sources
Isothiazolinones as Novel Candidate Insecticides for the Control of Hemipteran Insects
Antibiotics, 2021 Hemipteran insects, such as whiteflies, aphids and planthoppers, resemble one of the most important pest groups threating food security. While many insecticides have been used to control these pests, many issues such as insecticide resistance have been ...
Wenze He +3 more
doaj +2 more sources
Isothiazolinones as causal factors of contact allergy epidemics in the 20th and 21st centuries [PDF]
Medycyna Pracy, 2014 Chloromethylisothiazolinone (MCI) and methylisothiazolinone (MI) have been widely used as preservatives in cosmetics, household products and industrial products since the late 1970s.
Dorota Chomiczewska-Skóra +2 more
doaj +3 more sources
The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel. [PDF]
Pharmacol Res PerspectABSTRACT Methylisothiazolinone (MIT) is a known inducer of allergic contact dermatitis that is used as a preservative and a biocide in consumer products. Transient receptor potential ankyrin 1 (TRPA1) is a non‐selective cation channel expressed in neurons and in some nonneuronal cells including keratinocytes.
Mäki-Opas I +4 more
europepmc +2 more sources