Results 31 to 40 of about 2,563 (255)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The effect of electrically heated humidifier on the body temperature and blood loss in spinal surgery under general anesthesia [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundGeneral anesthesia often produces some degree of hypothermia and hypothermia causes much more blood loss during surgery than normothermia. Electrically heated humidifiers (EHHs) have been used for patients under general anesthesia and in the ...
Hyun Kyu Lee, Yeon-Hee Jang, Kwan-Woong Choi, Jae Ho Lee   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A flue gas moisture separation for the CCS systems using membrane condensation [PDF]

EPJ Web of Conferences
Currently, in connection with the use of combustion with only pure oxygen (oxyfuel), the issue of energy-efficient moisture separation from flue gases before the storage or the use of CO2 is being intensively studied.
Kolovratník Michal, Petr Václav, Bartoš Ondřej   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prediction of the Effect of Polymer Membrane Composition in a Dry Air Humidification Process via Neural Network Modeling [PDF]

Iranian Journal of Chemical Engineering, 2016
Utilization of membrane humidifiers is one of the methods commonly used to humidify reactant gases in polymer electrolyte membrane fuel cells (PEMFC).
M. Fakhroleslam, A. Samimi, S.A. Mousavi, R. Rezaei   +3 more
doaj  

MODERN VIEW ON TRACHEOSTOMY

Наука и инновации в медицине, 2018
Aim - optimization of postoperative period in tracheostomy patients. Materials. Since 2016 we have followed up 48 patients with stenosis of the larynx and trachea of various etiologies, all the patients underwent urgent tracheostomy. Methods.
M U Zamanov, N A Miroshnichenko, A Yu Ovchinnikov, D G Gorban, V A Ekaterinchev   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Multi-objective optimization of a PEMFC based CCHP system by meta-heuristics

Energy Reports, 2019
This paper presents a multi-criteria economics, environment, and thermodynamics assessment for a combined cooling, heating, and power (CCHP) system consist of a heat recovery system, a small absorption chiller, a 5kW PEMFC stack, gas compressor, and a ...
Yan Cao, Yujia Wu, Leijie Fu, Kittisak Jermsittiparsert, Navid Razmjooy   +4 more
doaj   +1 more source