Results 61 to 70 of about 1,012,376 (308)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Study on the influence of inlet air relative humidity on temperature and moisture of warehouse grain stack during ventilation

open access: yesLiang you shipin ke-ji, 2020
Temperature and moisture content are two important physical variables that play a considerable role in the study of quality changes during grain storage.
WANG Yi, QI Yu-kang, KONG Ling-jin
doaj   +1 more source

Precise control of operating conditions in tribotesting with respect to trace humidity and contact temperature

open access: yesMethodsX, 2021
Research in tribology are often connected to tribosystems operating in specific environments, where climate chambers are needed for tribotesting to resemble the environmental conditions in the real application.
Pontus Johansson   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Temperature and humidity control of simulated human breath [PDF]

open access: yes, 1972
Subsystem was developed for breathing metabolic simulator which adjusts temperature and humidity of air to levels of human exhaled breath. Temperature-humidity subsystem is described, consisting of aluminum enclosure with 400 watt heat sheet glued to ...
Bartlett, R. G., Hendricks, C. M.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Pengendalian Temperatur dan Kelembaban dalam Kumbung Jamur Tiram (Pleurotus sp) Secara Otomatis Berbasis Mikrokontroler

open access: yesAgritech, 2019
Oyster mushroom can grow properly at temperatures of 16–30 °C and relative humidity of 80–95%. Environment conditioning by spraying of water in mushroom house manually in the morning and evening as the temperature and humidity controling is less ...
Sri Waluyo   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Experience of Implementing Moisture Sorption Control in Historical Archives

open access: yesActa Polytechnica, 2006
This paper deals with a novel approach to inhibiting the harmful impact of moisture sorption in old art works and historical exhibits preserved in remote historic buildings that are in use as depositories or exhibition rooms for cultural heritage ...
P. Zítek, T. Vyhlídal, J. Chyský
doaj  

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