Results 111 to 120 of about 468,847 (270)

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

open access: yesAdvanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang   +17 more
wiley   +1 more source

Evaluating the Interpersonal Nature of Humor: Mapping Humor Styles Onto the Interpersonal Circumplex [PDF]

open access: yes, 2012
The present study examined the interpersonal content of the four humor styles outlined in the Humor Styles Questionnaire in order to gather additional information about the interpersonal content of these humor styles.
Vaughan, Jessica Erin
core  

Choosing One’s Words: Conversational Indirectness and Humor Style in Two Distinct Cultural Groups

open access: yesBehavioral Sciences
We investigated cultural differences in the relationship between conversational indirectness and styles of humor use. Our study compared responses of English first language (L1) users (n = 56) and Korean first language users studying in the US (n = 32 ...
Tanisha Y. Berrios   +2 more
doaj   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

open access: yesAdvanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen   +17 more
wiley   +1 more source

Relationship between styles of humor and divergent thinking [PDF]

open access: yes, 2010
The aim of the present study was to investigate the relationship between styles of humor and divergent thinking of Turkish 6th, 7th, and 8th grade students. Styles of humor were measured by Humor Style Questionnaire and divergent thinking was measured by
Cayirdag, Nur, Acar, Selcuk
core   +1 more source

THE EFFECT OF HUMOR STYLES OF PREGNANT WOMEN ON DISTRESS

open access: yesEastern Journal of Medical Sciences, 2019
Objectives: This study was conducted to determine the effect of pregnant women’s humor styles on distress. Methods: A descriptive study was conducted on pregnant women who have applied to the Maternity Hospital Non-stress Test unit in the city of Erzurum from 1 August 2014 to 31 December 2014.
Kanbur, Ayla   +3 more
openaire   +4 more sources

Anion‐Driven Surface Reconstruction Enables Direct Regeneration of LiCoO2 Cathode Material

open access: yesAdvanced Science, EarlyView.
The anion scpecies in molten salt systems critically govern the surface reconstruction of regenerated LiCoO2. LiOH−LiCl flux, featuring strong Cl− adsorption and facile dissociation, directs preferential relithiation on (003) facets and forms a Li−O enriched interface.
Mengting Zheng   +4 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang   +12 more
wiley   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

open access: yesAdvanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen   +11 more
wiley   +1 more source

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