Results 71 to 80 of about 148,680 (286)

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan   +8 more
wiley   +1 more source

Sense of Humor, Stable Affect, and Psychological Well-Being

open access: yesEurope's Journal of Psychology, 2014
A good sense of humor has been implicated as a quality that could contribute to psychological well-being. The mechanisms through which sense of humor might operate include helping to reappraise threats, serving as a character strength, or facilitating ...
Arnie Cann, Chantal Collette
doaj   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

open access: yesAdvanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang   +10 more
wiley   +1 more source

Is opioid dependency related to coping strategies? [PDF]

open access: yes, 2015
Using opioid for recreational purposes has a very long history in Iran. Social influence is a useful framework in understanding how the social environment affects the individual's behavioral choices to use drugs.
Behnampour, N.   +4 more
core   +1 more source

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

open access: yesAdvanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin   +19 more
wiley   +1 more source

Humor styles in the classroom: students’ perceptions of lecturer humor

open access: yesHUMOR
Abstract Previous research has shown that humor can have an impact on people’s interpersonal relationships and the way they are perceived by others. In addition, it has been suggested that use of humor by teachers can be positive, but also negative.
James, Lucy, Fox, Claire
openaire   +4 more sources

GAYA BAHASA SATIRE DALAM PROGRAM PINGIN SIARAN PADA YOUTUBE MAJELIS LUCU INDONESIA (MLI) [PDF]

open access: yes, 2023
This research examines the elements, forms and context of satirical language styles in the Pingin Siaran program on the Majelis Lucu Indonesia’s YouTube. Using a form of satire to increase insight into the use of language styles, especially satire.
Ilmiawan, Mukhammad Ilham
core  

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

open access: yesAdvanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl   +27 more
wiley   +1 more source

Comparsion of Alexithymia, Self-Compassion and Humor Styles between Parents of Children with Mental Retardation and Normal Children [PDF]

open access: yesRavānshināsī-i Afrād-i Istis̠nāyī, 2018
The purpose of this study was to Compare of Alexithymia, Self-Compassion and Humor Styles between Parents of Children with Mental Retardation and Normal Children. The research method is then causal-comparative. The research method was causal-comparative.
Hiva Mahmoodi   +2 more
doaj   +1 more source

Hearts-on Approach to Educational Leadership [PDF]

open access: yes, 2008
Christian educational leaders come equipped with an arsenal of skills, talents, and beliefs rooted in their faith. The synthesis of faith in their daily lives or “hearts-on” approach provides them a solid foundation. Communication is the most important
Adams, Russell H
core   +1 more source

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