Results 111 to 120 of about 182,481 (302)

Humoral immunity in Hansen's Disease

São Paulo Medical Journal
For many years immune response in leprosy has been studied. Since 1960 several reports dealing with humoral immunity have been described in the literature. Different autoantibody rates occur in leprosy.
Waldenise Cossermelli-Messina, Wilson Cossermelli   +1 more
doaj   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development

Journal of Immunology Research, 2015
Although tuberculosis remains a major global health problem, Bacille Calmette-Guérin (BCG) is the only available vaccine. However, BCG has limited applications, and a more effective vaccine is needed. Cellular mediated immunity (CMI) is thought to be the
Mamiko Niki, Maho Suzukawa, Shunsuke Akashi, Hideaki Nagai, Ken Ohta, Manabu Inoue, Makoto Niki, Yukihiro Kaneko, Kozo Morimoto, Atsuyuki Kurashima, Seigo Kitada, Sohkichi Matsumoto, Koichi Suzuki, Yoshihiko Hoshino   +13 more
doaj   +1 more source

Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Relieves Immunosuppression in Cyclophosphamide-Treated Geese by Maintaining a Humoral and Cellular Immune Balance

Molecules, 2018
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) has been well recognized as an immune enhancer that can promote lymphocyte proliferation and activate immune cells.
Wanyan Li, Sixuan Guo, Danning Xu, Bingxin Li, Nan Cao, Yunbo Tian, Qingyan Jiang   +6 more
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection [PDF]

, 2014
Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality.
F. Moalli, Moalli, Federica, G. Graziani, Alemka Markotic, L. Cvetko Krajinovic, Eduardo Bonavita, Federica Riva, Krajinovic, Lidija, Doni, Andrea, A. Doni, Tartari, Silvia, Sonia Valentino, Bonavita, Eduardo, Catharina Svanborg, Ragnarsdottir, Bryndis,, Svanborg, Catharina,, C. Svanborg, Cecilia Garlanda, C. Garlanda, S. Jaillon, Jaillon, Sébastien, Silvia Tartari, Giorgio Graziani, Mantovani, Alberto, Alberto Mantovani, Nebuloni, Manuela, Lidija Cvetko Krajinovic, L.Cvetko Krajinovic, Yves Delneste, A. Markotic, Markotic, Alemka, Lund University., Y. Delneste, Garlanda, Cecilia, E. Barbati, Graziani, Giorgio, Puthia, Manoj, Delneste, Yves, S. Tartari, Bryndis Ragnarsdottir, Barbati, Elisa, Puthia, Manoj,, M. Puthia, Valentino, Sonia, Federica Moalli, Andrea Doni, Cvetko Krajinovic, Lidija, Alessandro Montanelli, S. Valentino, Manuela Nebuloni, B. Ragnarsdottir, Elisa Barbati, Svanborg, Catharina, Manoj Puthia, F. Riva, A. Montanelli, Ragnarsdottir, Bryndis, Montanelli, Alessandro, A. Mantovani, Sébastien Jaillon, Riva, Federica, M. Nebuloni, E. Bonavita   +62 more
core   +2 more sources

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Humoral and cellular factors of maternal immunity in swine [PDF]

, 2009
International audienceImmunoglobulins cannot cross the placenta in pregnant sows. Neonatal pigs are therefore agammaglobulinemic at birth and, although immunocompetent, they cannot mount rapid immune responses at systemic and mucosal sites.
Henri Salmon, Salmon, Henri, H., Meurens, Francois, François Meurens, Berri, Mustapha, M., Gerdts, V, Volker Gerdts, Mustapha Berri   +7 more
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Current perspectives in assessing humoral immunity after measles vaccination [PDF]

, 2019
Introduction: Repeated measles outbreaks in countries with relatively high vaccine coverage are mainly due to failure to vaccinate and importation; however, cases in immunized individuals exist raising questions about suboptimal measles vaccine-induced ...
Gregory A. Poland, Daniel J. Schaid, Richard B. Kennedy, Iana H. Haralambieva, Inna G. Ovsyannikova   +4 more
core   +1 more source