Results 101 to 110 of about 182,481 (302)

Short-Circuiting Long-Lived Humoral Immunity by the Heightened Engagement of CD40 [PDF]

, 2002
Agonistic αCD40 Ab’s have been shown to be potent immune adjuvants for both cell- and humoral-mediated immunity. While enhancing short-lived humoral immunity, the administration of a CD40 agonist during thymus-dependent immune responses ablates germinal ...
Hitoshi Kikutani, Teruhito Yasui, Brigit G. Durell, Brian P. O’Connor, Vogel, Laura A, Marilia Cascalho, Connor, Brian P, Cascalho, Marilia, Durell, Brigit G, Laura A. Vogel, Loren D. Erickson, Randolph J. Noelle, Noelle, Randolph J, Erickson, Loren D, Yasui, Teruhito, Kikutani, Hitoshi   +15 more
core   +2 more sources

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Characterisation of immune responses to varicella vaccination in relation to clinical outcome [PDF]

, 2010
PhDThis thesis examines both humoral and cellular adaptive immune responses to varicella vaccination (up to 18 months post immunisation), in an ethnically diverse population of healthcare workers.
McDonald, Suzanna Leonie Rose
core  

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation [PDF]

Endothelial function and integrity are compromised after allogeneic bone marrow transplantation (BMT), but how this affects immune responses broadly remains unknown.
Waltner, OG, Daly, S, Voigt, V, Olver, S, Zhang, P, Bhise, SS, McEnroe, BA, Saldan, A, Varelias, A, Fleming, P, Andoniou, CE, Henden, AS, Ekwe, AP, Martins, JP, Kuns, RD, et al.   +15 more
core   +1 more source

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Rizwan Hamer, Imray, C. (Chris), Nithya S Krishnan, Lam Chin Tan, Higgins Robert M., Daga Sunil, Lowe, David Philip, David Briggs, Zehnder Daniel, Tan Lam Chin, Zehnder, Daniel, Robert M Higgins, Daniel Zehnder, Kashi Habib, Dave Lowe, Christopher Imray, Sunil Daga, Neil Raymond, Krishnan, Nithya S., Lam, F. T., Higgins, Rob, Lam F. T., Habib Kashi, Daga, Sunil, F T Lam, Krishnan Nithya S., Lowe Dave, Hamer, Rizwan, Briggs David, Kashi, Habib, Briggs, David, Dr., Raymond Neil, Raymond, Neil T., Hamer Rizwan, Tan, Lam Chin, Imray Christopher   +35 more
core   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Cellular and humoral immunity in children with asthma [PDF]

, 2017
Asthma – is a chronic inflammatory disease of the airways, which most researchers attribute to allergic diseases which are based on immunological mechanisms, essentially even at present the subject of numerous studies.
V. M. Dudnyk, K. V. Khromykh, Fedchushen, A. P., A. P. Fedchushen, Khromykh, K. V., Dudnyk, V. M.   +5 more
core   +1 more source

Behavior of natural and humoral immunity in hypertension

Acta Médica del Centro, 2013
The changes that occur in response to stress are divided into “central adaptations” and “peripheral adaptations”. Within the latter there are the changes in the cardiovascular system (increased pulse and blood pressure), which are not sufficient in the ...
Lay Salazar Torres, Leticia Bequer Mendoza, Tahiry Gómez Hernández, Lutgarda Pérez de Alejo Rodríguez, Francisco Acosta de Armas   +4 more
doaj  

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

Nature Communications
Germinal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient distribution such as ...
Xingxing Zhu, Yue Wu, Yanfeng Li, Xian Zhou, Jens O. Watzlawik, Yin Maggie Chen, Ariel L. Raybuck, Daniel D. Billadeau, Virginia Smith Shapiro, Wolfdieter Springer, Jie Sun, Mark R. Boothby, Hu Zeng   +12 more
doaj   +1 more source