Results 81 to 90 of about 182,481 (302)

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity [PDF]

, 2017
To explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of ...
Lingyu Yang, Xu, Ke, Ronghua Dai, Paul Siegel, Ding, Jinmei, Meng, He, Chuan He, Liu, Shuyun, He, Chuan, Ke Xu, Yang, Lingyu, Siegel, Paul B., Jinmei Ding, Christa F. Honaker, He Meng, Honaker, Christa F., Shuyun Liu, Yan Zhang, Dai, Ronghua, Zhang, Yan   +19 more
core   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Immunomodulation by diet : individual differences in sensitivity in layer hens [PDF]

, 2009
Enhancing relevant immunity of production animals to achieve more robust animals is receiving more and more attention. Several epidemics have hit production animals recently and with devastating consequences, but enhancing diseases resistance ...
Adriaansen-Tennekes, R.
core  

Antibody levels to multiple malaria vaccine candidate antigens in relation to clinical malaria episodes in children in the Kasena-Nankana district of Northern Ghana. [PDF]

, 2011
BACKGROUND: Considering the natural history of malaria of continued susceptibility to infection and episodes of illness that decline in frequency and severity over time, studies which attempt to relate immune response to protection must be longitudinal ...
Ansah, Patrick, Kwadwo A Koram, Ansah Patrick, Ansah Nana, Beverly Egyir, Abraham Hodgson, Gyan, Ben, Dodoo, Daniel, Lamptey, Helena, Koram, Kwadwo A, Daniel DanielDodoo, Ansah, Nana Akosua, Atuguba, Frank, Egyir, Beverly, Samuel Bosomprah, Oduro, Abraham R, Hodgson, Abraham, Bosomprah Samuel, Hodgson Abraham, Gyan Ben, Daniel Dodoo, Oduro Abraham R, Egyir Beverly, Nana Akosua Ansah, Ben Gyan, Helena Lamptey, Frank Atuguba, Koram Kwadwo A, Lamptey Helena, Dodoo Daniel, Patrick Ansah, Atuguba Frank, Bosomprah, Samuel, Nana Ansah, Abraham R Oduro   +34 more
core   +1 more source

INFLUENCE OF COLURIA GEOIDES (ROSACEAE) BAC ON HUMORAL IMMUNE RESPONCE

Фармация и фармакология (Пятигорск), 2015
The article presents the results of immunocorrecting properties of dry extract fractions of C. geoides (Rosaceae) for experimental immunodeficiency. Since the BAC fractions action relinquishes to the action of integral extract, the isolation of active ...
S. V. Dutova, D. S. Dikhtyarov, D. R. Aukhodeev, Yu. V. Rostovtseva, M. R. Karpova   +4 more
doaj   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

Immunity, life history and conservation in the Galapagos sea lion [PDF]

, 2012
Infectious disease threatens health and biodiversity across the globe, and disease emergence may become more common as humans further encroach on habitats and modify environments. To assess the risks of disease emergence in natural populations accurately,
Brock, Patrick Michael
core  

Association between humoral immunity and clinical outcomes of patients after out-of-hospital cardiac arrest and resuscitation: a retrospective study

BMC Emergency Medicine
Background Patients with out-of-hospital cardiac arrest (OHCA) suffer from hypoxia-ischemia and ischemia-reperfusion injury (IRI) after the return of spontaneous circulation (ROSC).
Zhenyu Shan, Xingsheng Wang, Le An, Chenchen Hang, Zihao Jiang, Weijie Cheng, Ziqi Zhong, Rui Shao, Ziren Tang   +8 more
doaj   +1 more source