Results 81 to 90 of about 157,648 (208)

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

Transient gingival inflammation is associated with epithelial dysfunction and systemic immune activation beyond clinical improvement

Journal of Periodontology, EarlyView.
Abstract Background The oral cavity significantly influences systemic health. Gingivitis, an early reversible stage of periodontal disease, may trigger systemic immune changes by facilitating bacterial translocation. This study examined the immune responses elicited by experimental gingivitis and their systemic immune impact, specifically in relation ...
Omnia Elebyary, Rachel Liu, Jinny Tsang, Chunxiang Sun, Bryan Coburn, Michael Glogauer   +5 more
wiley   +1 more source

Surveying immune and inflammatory alterations in periodontitis among individuals with Down syndrome: A preliminary cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background Individuals with Down syndrome (DS) are particularly vulnerable to early‐onset and rapidly progressing periodontitis, yet the local immune‐inflammatory alterations that contribute to this susceptibility are not fully understood. This study aimed to characterize cytokine profiles in gingival crevicular fluid (GCF) from individuals ...
Leticia Helena Theodoro, João Victor Soares Rodrigues, Marta A. A. Nuernberg, Pedro Henrique Petrilli, Mabelle de Freitas Monteiro, Valdir Gouveia Garcia, Rafael Scaf de Molon, Renato Correa Viana Casarin   +7 more
wiley   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Oral PHGG ameliorates atopic dermatitis‐like dermatitis with concurrent modulation of colonic IgA and cecal microbiota: implications for the gut–skin axis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza, Hyeonjun Yu, Jonghyun Jeong, Jung Cheul Shin, Woo Jung Kim, Sung‐Kwon Moon, Hoon Kim   +6 more
wiley   +1 more source

Refractory Eczema as a Presenting Feature of Common Variable Immunodeficiency

JEADV Clinical Practice, EarlyView.
ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic inborn error of immunity (IEI) in adults. It presents with recurrent infections and non‐infectious complications, including autoimmunity, lymphoproliferation and dermatitis.
Mercedes Sanchez‐Diaz, Lars Matthies, Andrea Vanegas Ramirez   +2 more
wiley   +1 more source

Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1‐nCoV‐19 Vaccine in Hemodialysis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang, Ping‐Hsun Wu, Li‐Yun Chang, Yu‐Ying Huang, Teng‐Hui Huang, Su‐Chu Lee, Yi‐wen Chiu, Shang‐Jyh Hwang, Tsun‐Yung Kuo, Mei‐Chuan Kuo   +9 more
wiley   +1 more source

Pneumococcal membrane particles promote serotype-independent cellular and humoral immunity and protect against pneumococcal colonization. [PDF]

Proc Natl Acad Sci U S A
Dookie R, Narciso AR, Gaytán MO, Narayana Moorthy A, Chakraborty S, Thorsdottir S, Boss J, Righetti F, Karlsson J, Heurgren M, Normark S, Henriques-Normark B.   +11 more
europepmc   +1 more source

Proteomics‐Based Identification of the Pyroptosis‐Related Biomarker PCSK9 and Its Association With the Pathogenesis of Rheumatoid Arthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang, Hao‐Jie Chen, Ting‐Ting Wu, Xin‐Yi Shen, Ying‐Ying Gao, Yu‐Feng Yin, Tian Ren, Xin Chu, Jing Cao, Tao Cheng, Ming‐Jun Wang   +10 more
wiley   +1 more source

Optimizing Humoral Immunity for Durable and Broad Protection in Flavivirus Vaccines. [PDF]

Vaccines (Basel)
Park JY, Lee HM.
europepmc   +1 more source