Results 61 to 70 of about 561,570 (286)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Characteristics of cellular and humoral immunity parameters in patients with mechanical jaundice, caused by cholangiocarcinoma

Инфекция и иммунитет, 2022
In the modern world, obstructive jaundice caused by developing a malignant disease cholangiocarcinoma, poses a significant medical and social problem in economically developed and in developing countries.
Olga V. Smirnova, B. G. Gubanov, E. V. Kasparov, M. A. Darenskaya, L. I. Kolesnikova, S. N. Kolesnikov   +5 more
doaj   +1 more source

Humoral Immunity in Polymyositis/Dermatomyositis

Journal of Investigative Dermatology, 1993
Autoantibodies are found in most patients with polymyositis (PM) or dermatomyositis (DM) and 35-40% of these patients have myositis-specific antibodies. Twenty-five to thirty percent have anti-aminoacyl-tRNA synthetases, of which anti-Jo-1, directed at histidyl-tRNA synthetase, is by far the most common.
openaire   +2 more sources

Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells [PDF]

, 2015
Calcineurin inhibitors (CNI), used frequently in solid organ transplant patients, are known to inhibit T cell proliferation, but their effect on humoral immunity is far less studied.
Bogaert, Delfien, Lambrecht, Bart, Dullaers, Melissa, R De Bruyne, Gevaert, P, De Bruyne, R, Van Winckel, M., De Bruyne, R., Gevaert, Philippe, De Ruyck, Natalie, Van Winckel, M, Lambrecht, B. N., M Dullaers, De Ruyck, N., D Bogaert, Bogaert, D, Gevaert, P. (P.), N De Ruyck, Bogaert, D.J.A. (Delfien), M Van Winckel, Dullaers, M., Van Winckel, Myriam, Bogaert, D., De Ruyck, N, P Gevaert, Gevaert, P., B N Lambrecht, De Bruyne, Ruth, Lambrecht, B.N.M. (Bart), Dullaers, M   +29 more
core   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Modulation of the primary humoral immunity by footshock and footshock signal

, 2000
The effects of footshock and footshock signal on humaoral immunity function and endocrine response after injection with ovalbumin (OVA) were examined in rats.
W. J. Lin, W. W. Wang, F. Shao
core   +1 more source

Assessing COVID IGRA and IgG antibodies in healthcare workers post vaccination

Journal of Infection in Developing Countries
Introduction: This study evaluated the durability of humoral and cell-mediated immunity (CMI) post Pfizer vaccination among healthcare workers (HCWs) at a tertiary care center in Lebanon.
Lina Ghandour, Wissam Yaacoub, George F Araj   +2 more
doaj   +1 more source

Five doses of the mRNA vaccination potentially suppress ancestral-strain stimulated SARS-CoV2-specific cellular immunity: a cohort study from the Fukushima vaccination community survey, Japan

Frontiers in Immunology, 2023
The bivalent mRNA vaccine is recommended to address coronavirus disease variants, with additional doses suggested for high-risk groups. However, the effectiveness, optimal frequency, and number of doses remain uncertain.
Yuta Tani, Morihito Takita, Morihito Takita, Masatoshi Wakui, Hiroaki Saito, Hiroaki Saito, Takamitsu Nishiuchi, Tianchen Zhao, Chika Yamamoto, Takeshi Kawamura, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Yudai Kaneko, Tatsuhiko Kodama, Ryuzaburo Shinaha, Masaharu Tsubokura, Masaharu Tsubokura, Masaharu Tsubokura   +19 more
doaj   +1 more source

Quantifying the waning of humoral immunity

Immunity
Abstract Immunological memory is a defining feature of immunity, yet surprisingly there is no consensus on how to quantitatively describe how antibody titers wane over time. A major problem is that the slow waning of antibody titers requires the collection of data for decades post-infection or vaccination.
Ananya Saha, Hasan Ahmed, Cora Hirst, Katia Koelle, Andreas Handel, Peter Teunis, Rustom Antia   +6 more
openaire   +3 more sources