Results 71 to 80 of about 182,481 (302)

Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine

Advanced Science, 2023
New vaccine platforms that activate humoral immunity and generate neutralizing antibodies are required to combat emerging pathogens, including influenza virus.
Hiromi Miwa, Olivia Q. Antao, Kindra M. Kelly‐Scumpia, Sevana Baghdasarian, Daniel P. Mayer, Lily Shang, Gina M. Sanchez, Maani M. Archang, Philip O. Scumpia, Jason S Weinstein, Dino Di Carlo   +10 more
doaj   +1 more source

Antibody and T-Cell Responses against SARS-CoV-2 after Booster Vaccination in Patients on Dialysis: A Prospective Observational Study

Vaccines, 2023
Intensive vaccination is recommended for populations more vulnerable to COVID-19 infection, although data regarding the built of immunity after vaccination for dialysis patients are lacking.
Moe Kawashima, Hiroaki Saito, Takamitsu Nishiuchi, Hiroki Yoshimura, Masatoshi Wakui, Yuta Tani, Yoshitaka Nishikawa, Fumiya Omata, Morihito Takita, Tianchen Zhao, Chika Yamamoto, Yurie Kobashi, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Toyoaki Sawano, Kenji Shibuya, Junichiro Kazama, Ryuzaburo Shineha, Masaharu Tsubokura   +20 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum [PDF]

, 2001
Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 ...
David R. Cavanagh, Cavanagh, D R, Cavanagh, DR, Ibrahim M. Elhassan, Elhassan, I M, Jana S. McBride, Theander, TG, Kevin Marsh, McBride, JS, Elhassan, A, Hviid, L, Khalil, E A T G, Ahmed Elhassan, Thor G. Theander, Cavanagh, David, Arnot, DE, Marsh, K, David E. Arnot, E. At Tahir G. Khalil, Khalil, EA, McBride, J S, Arnot, D E, Elhassan, IM, Theander, T G, Marsh, Kevin, Lars Hviid, Dobano, C, Carlota Dobaño, Khalil, E A   +28 more
core   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

The effects of emotional stress on the primary humoral immunity in rats [PDF]

, 2000
The effect of exposure to emotional stress on humoral immunie functiion after injection with a novel antigen, ovalbumin (OVA), was studied in rats.Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at set ...
W. J. Lin, F. Shao, C. Washington
core  

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
Porcelli, SA, Wang, Yanhua, Steven A. Porcelli, William R Jacobs, Flynn, Joanne L, Chen, Y, John Chan, Kozakiewicz, Lee, Qinglin Ou, Lee Kozakiewicz, Chan, John, Xu, J, Ou, Qinglin, Yong Chen (109188), John Chan (47914), Jacobs, WR, Flynn, JL, Ou, Q, Jacobs, William R, William R. Jacobs, Dunussi-Joannopoulos, K, Dunussi-Joannopoulos, Kyri, Steven A. Porcelli (47915), Chen, Yong, Joanne L Flynn, Xu, Jiayong, Kozakiewicz, L, Jiayong Xu (432778), Wang, Y, Joanne L. Flynn (5655565), William R. Jacobs Jr (199645), Chan, J, Lee Kozakiewicz (432777), Qinglin Ou (432779), Joanne L. Flynn, Yanhua Wang, Porcelli, Steven A, Yanhua Wang (127897), Jiayong Xu, Steven A Porcelli, Yong Chen, Kyri Dunussi-Joannopoulos, Kyri Dunussi-Joannopoulos (344714)   +42 more
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source