Results 71 to 80 of about 561,570 (286)

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

SARS-CoV-2 Infection Enhances Humoral Immune Response in Vaccinated Liver Transplant Recipients

In the spring of 2020, the SARS-CoV-2 pandemic presented a formidable challenge to national and global healthcare systems. Immunocompromised individuals or those with relevant pre-existing conditions were particularly at risk of severe coronavirus ...
Jörn Arne Meier, Jan Basri Adiprasito, Florian Rennebaum, Phil-Robin Tepasse, Jonel Trebicka, Tina Schomacher, Julia Fischer, Eva U. Lorentzen, Tobias Nowacki, Richard Vollenberg   +9 more
core   +1 more source

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source

HUMORAL IMMUNITY TO HUMAN NEOPLASMS [PDF]

Iranian Journal of Public Health, 1974
Using complement fixation technique, serial serum samples from 15 patients undergoing surgical removal of malignant tumors were assayed for the presence of tumors antibodies against the cellular fractions of both normal and carcinomatous tissue. Antibody
D. Shadafza, N. Mohagheghpour
doaj   +1 more source

Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine

Advanced Science, 2023
New vaccine platforms that activate humoral immunity and generate neutralizing antibodies are required to combat emerging pathogens, including influenza virus.
Hiromi Miwa, Olivia Q. Antao, Kindra M. Kelly‐Scumpia, Sevana Baghdasarian, Daniel P. Mayer, Lily Shang, Gina M. Sanchez, Maani M. Archang, Philip O. Scumpia, Jason S Weinstein, Dino Di Carlo   +10 more
doaj   +1 more source

Humoral Immunity across the SARS-CoV-2 Spike after Sputnik V (Gam-COVID-Vac) Vaccination

SARS-CoV-2 vaccines have contributed to attenuating the burden of the COVID-19 pandemic by promoting the development of effective immune responses, thus reducing the spread and severity of the pandemic.
Rossana Celeste Jaspe, García Piñero, Alexis H., Mariajose Rodriguez-Nuñez, Nereida Parra-Giménez, Franklin Ennodio Claro, de Waard, Jacobus Henri, Liprandi, Ferdinando, Rangel, Héctor Rafael, Hidalgo, Mariana, Claro, Franklin Ennodio, Mayora, Soriuska, Inirida Belisario, José Luis Zambrano, Jaspe, Rossana Celeste, Ferdinando Liprandi, Parra-Giménez, Nereida, Alexis García, Flor Helene Pujol, Zambrano, José Luis, Garzaro, Domingo José, Pujol, Flor Helene, Belisario, Inirida, Rodríguez-Nuñez, Mariajose, Alejandro Cornejo, Christopher Franco, Jacobus Henri de Waard, Héctor Rafael Rangel, Franco, Christopher, Cornejo, Alejandro, Mariana Hidalgo, Soriuska Mayora, Domingo José Garzaro   +31 more
core   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Comparing population-level humoral and cellular immunity to SARS-Cov-2 in Bangalore, India

Scientific Reports
Two types of immunity, humoral and cellular, offer protection against COVID. Humoral protection, contributed by circulating neutralizing antibodies, can provide immediate protection but decays more quickly than cellular immunity and can lose ...
Anup Malani, Jayashree Aiyar, Andrea Sant, Neha Kamran, Manoj Mohanan, Saloni Taneja, Bartek Woda, Wanran Zhao, Anu Acharya   +8 more
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source