Results 211 to 220 of about 561,570 (286)

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

IL-6-induced C/EBPα drives follicular regulatory T cell differentiation to regulate humoral immunity in mice. [PDF]

Nat Commun
Lee H, Kim CJ, Ahn H, Cho G, Mun SH, Kim SW, Choi HS, Um D, Kim H, Ko H, Noh J, Park JC, Park HE, Sharma A, Lee Y, Lee SW, Choi YS, Suh CH, Kim JW, Kim TK, Hwang CS, Kim JK, Kim S, Im SH.   +23 more
europepmc   +1 more source

PTEN-mTORC2 signaling module controls antibody isotype selection and antiviral humoral immunity. [PDF]

Front Immunol
Thapa B, Lee Y, Pak S, Kim D, Kwon HJ, Lee K.   +5 more
europepmc   +1 more source

Humoral immunity and infection status of PLWH following vaccination after the BA.5/BF.7 wave. [PDF]

Front Microbiol
Xie Y, Song X, Yang L, Wang L, Gao H, Zhang L, Feng Y, Chen Y, Yan H, Feng F, Dai E, Wang Y, Feng A.   +12 more
europepmc   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Immunoglobulin allotypes and <i>RELN</i> alleles and humoral immunity to HSV1 in patients with Alzheimer's disease and matched controls. [PDF]

J Alzheimers Dis
Pandey JP, Namboodiri AM, Nietert PJ.
europepmc   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

A p53 peptide mucosal vaccine induces cellular and humoral immunity and anti-tumor effects in a murine colorectal cancer model. [PDF]

Cancer Gene Ther
Wang SH, Cao Z, Janczak KW, Feng Y, Green M, Tang S, Fearon ER, Baker JR.   +7 more
europepmc   +1 more source

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

Med Research, EarlyView.
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang, Fen Yang, Xingji Lian, Jie He, Shuijin Huang, Mingjuan Fan, Yin Liang, Jiaqiang Huang, LongYan Yin, Hong Wang   +9 more
wiley   +1 more source

Dietary supplementation of arachidonic acid promotes humoral immunity. [PDF]

EMBO Mol Med
Feng S, Ma E, Na X, Wang Z, Tai W, Bao X, Wang M, Chang H, Wu B, Liu M, Li J, Shi H, Yang C, Xi M, Yang H, Li Y, Zhu Y, Wang P, Zhao L, Zhao A, Cheng G.   +20 more
europepmc   +1 more source